Dantrolene sodium in children with spasticity

R. H.A. Haslam, J. R. Walcher, P. S. Lietman, C. H. Kallman, E. D. Mellits

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


The efficacy of dantrolene sodium was evaluated in 23 children with spasticity related to brain damage incurred at birth. Intelligence was subnormal in all cases. For neurologic testing, a clinical grading system for spasticity was devised; similarly, the therapists devised means for assessing changes in motor function and self help skills. Nurses evaluated changes in the ease or difficulty of carrying out routine daily activities. Statistical analysis was based on quantitative scores on neurologic components of spasticity, with controls provided by 'within subject' techniques. Results of double blind crossover testing showed that dantrolene sodium produced improvement in all neurologic measures tested except clonus, with statistically significant values in reflexes and 'scissoring'. Significant improvement was demonstrated in self help skills. No important side effects or drug reactions were observed.

Original languageEnglish (US)
Pages (from-to)384-388
Number of pages5
JournalArchives of physical medicine and rehabilitation
Issue number8
StatePublished - 1974
Externally publishedYes

ASJC Scopus subject areas

  • Physical Therapy, Sports Therapy and Rehabilitation
  • Rehabilitation


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