D-light autofluorescence in the detection of premalignant airway changes: A multicenter trial

Armin Ernst, Michael J. Simoff, Praveen N. Mathur, Rex C. Yung, John F. Beamis

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


Carcinoma in situ and preinvasive lesions are difficult to detect by white light (WL) bronchoscopy. Autofluorescence (AF) bronchoscopy is an emerging technology that may increase the ability for early detection and curative treatment. We report on the effectiveness of an autofluorescence system to detect class III lesions in a large population. A multicenter prospective, nonrandomized, self-controlled study was performed in 5 university-affiliated tertiary care centers. Patients at high risk for pulmonary malignancies were eligible to undergo WL and AF bronchoscopy. Patients underwent biopsy of all suspicious class III lesions, as well as 2 biopsies from normal areas. Three hundred patients were included in the study; of those, 293 patients were included into the efficacy calculations with 832 biopsies. AF was superior to WL in sensitivity (61.2% vs. 10.6%) for detecting class III lesions (visual changes suggesting dysplasia, carcinoma in situ, or microinvasive cancer). The combined sensitivity was 65.9%. Specificity values were 75.3% and 72.7%, respectively, for AF and WL. On a per-patient basis harboring at least 1 premalignant area, the sensitivity for WL was 21.1% as compared with 84.2% for AF. Three deaths occurred within the study period but were unrelated to the device. In conclusion, the AF system is superior to conventional WL bronchoscopy in detecting premalignant lesions in a population at risk.

Original languageEnglish (US)
Pages (from-to)133-138
Number of pages6
JournalJournal of Bronchology
Issue number3
StatePublished - Jul 2005


  • Autofluorescence
  • Bronchoscopy
  • Lung cancer
  • Screening

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


Dive into the research topics of 'D-light autofluorescence in the detection of premalignant airway changes: A multicenter trial'. Together they form a unique fingerprint.

Cite this