Cytomegaloviremia in children with acute lymphocytic leukemia

Frederick Cox, Walter T. Hughes

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Leukocyte and urine cultures were done at monthly intervals in 36 children with acute lymphocytic leukemia known to be excreting cytomegalovirus in their urine or saliva in order to determine the relationship of viremia to clinical cytomegalic inclusion disease. Eleven of 36 (30.5%) patients had viremia. Viremia was related to clinical disease in only three patients; two with chorioretinitis and one with a CMV mononucleosis syndrome. However, the presence of viremia did not serve as a useful means to determine active CID. Viremic patients with CID all had elevated serum levels of IgM and multiple episodes of viremia. Viremia was not related to the duration, type or number of drugs used in immunosuppression, nor to the hematologic status of leukemia. Viremic patients received more blood transfusions than noviremic patients, but the administration of blood products could not be related to the acquisition of infection. Leukopenia, neutropenia, total lymphocyte count, fourfold rise or fall in complement-fixing titer, and viruria had no consistent relationship to viremia or clinical CID.

Original languageEnglish (US)
Pages (from-to)190-194
Number of pages5
JournalThe Journal of pediatrics
Issue number2
StatePublished - Aug 1975
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


Dive into the research topics of 'Cytomegaloviremia in children with acute lymphocytic leukemia'. Together they form a unique fingerprint.

Cite this