Cytokine imbalance in acute coronary syndrome

Samir E. Alam, Samer S. Nasser, Khaled E. Fernainy, Aida A. Habib, Kamal F. Badr

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


The excessive mortality of coronary heart disease is attributed primarily to rupture and thrombotic transformation of the atherosclerotic plaque. Inflammation plays a critical role in plaque destabilization and vulnerability. Inflammation is not confined to the culprit segment but is convincingly widespread in the coronary and remote vascular beds. Systemic inflammatory, thrombotic and hemodynamic factors are relevant to the pathological and clinical outcome. In addition to their fundamental role in thrombosis, there is ample evidence that platelets contribute significantly to promoting plaque inflammation. A new paradigm of unbalanced cytokine-mediated inflammation is emerging, providing diagnostic and therapeutic opportunity for intervention. Amplifying intrinsic anti-inflammatory mechanisms constitutes attractive avenues for future investigation.

Original languageEnglish (US)
Pages (from-to)166-170
Number of pages5
JournalCurrent Opinion in Pharmacology
Issue number2
StatePublished - Apr 2004
Externally publishedYes

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology


Dive into the research topics of 'Cytokine imbalance in acute coronary syndrome'. Together they form a unique fingerprint.

Cite this