Cytokine gene expression in cells derived from CSF of multiple sclerosis patients

P. A. Calabresi; L. R. Tranquill; H. F. McFarland; E. P. Cowan

doi:10.1016/S0165-5728(98)00139-8

Cytokine gene expression in cells derived from CSF of multiple sclerosis patients

P. A. Calabresi, L. R. Tranquill, H. F. McFarland, E. P. Cowan

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

Cytokines are produced by numerous cell types in the peripheral blood and central nervous system (CNS), and have been implicated in the immunopathogenesis of multiple sclerosis (MS). We examined the relationship between cytokine gene expression of cerebrospinal fluid (CSF) derived cells from MS patients and disease activity as measured by contrast enhanced MRI. There was a significant correlation between the number of CSF cells and the number of contrast enhancing MRI lesions. Cytokine gene expression of TNF- α, IFN-γ and IL-10 was routinely seen, but IL-4 expression was absent except in two clinically quiescent patients. Trends were observed toward decreased TNF-α expression, but increased IL-10 expression, after treatment with IFN-β1b.

Original language	English (US)
Pages (from-to)	198-205
Number of pages	8
Journal	Journal of Neuroimmunology
Volume	89
Issue number	1-2
DOIs	https://doi.org/10.1016/S0165-5728(98)00139-8
State	Published - Aug 14 1998
Externally published	Yes

Keywords

Interferon
Interleukin
MRI
PCR
Tumor necrosis factor

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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abstract = "Cytokines are produced by numerous cell types in the peripheral blood and central nervous system (CNS), and have been implicated in the immunopathogenesis of multiple sclerosis (MS). We examined the relationship between cytokine gene expression of cerebrospinal fluid (CSF) derived cells from MS patients and disease activity as measured by contrast enhanced MRI. There was a significant correlation between the number of CSF cells and the number of contrast enhancing MRI lesions. Cytokine gene expression of TNF- α, IFN-γ and IL-10 was routinely seen, but IL-4 expression was absent except in two clinically quiescent patients. Trends were observed toward decreased TNF-α expression, but increased IL-10 expression, after treatment with IFN-β1b.",

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AU - Calabresi, P. A.

AU - Tranquill, L. R.

AU - McFarland, H. F.

AU - Cowan, E. P.

PY - 1998/8/14

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N2 - Cytokines are produced by numerous cell types in the peripheral blood and central nervous system (CNS), and have been implicated in the immunopathogenesis of multiple sclerosis (MS). We examined the relationship between cytokine gene expression of cerebrospinal fluid (CSF) derived cells from MS patients and disease activity as measured by contrast enhanced MRI. There was a significant correlation between the number of CSF cells and the number of contrast enhancing MRI lesions. Cytokine gene expression of TNF- α, IFN-γ and IL-10 was routinely seen, but IL-4 expression was absent except in two clinically quiescent patients. Trends were observed toward decreased TNF-α expression, but increased IL-10 expression, after treatment with IFN-β1b.

AB - Cytokines are produced by numerous cell types in the peripheral blood and central nervous system (CNS), and have been implicated in the immunopathogenesis of multiple sclerosis (MS). We examined the relationship between cytokine gene expression of cerebrospinal fluid (CSF) derived cells from MS patients and disease activity as measured by contrast enhanced MRI. There was a significant correlation between the number of CSF cells and the number of contrast enhancing MRI lesions. Cytokine gene expression of TNF- α, IFN-γ and IL-10 was routinely seen, but IL-4 expression was absent except in two clinically quiescent patients. Trends were observed toward decreased TNF-α expression, but increased IL-10 expression, after treatment with IFN-β1b.

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KW - Interleukin

KW - MRI

KW - PCR

KW - Tumor necrosis factor

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Cytokine gene expression in cells derived from CSF of multiple sclerosis patients

Abstract

Keywords

ASJC Scopus subject areas

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