Cysteine proteases from bloodfeeding arthropod ectoparasites

Daniel Sojka, Ivo M.B. Francischetti, Eric Calvo, Michalis Kotsyfakis

Research output: Chapter in Book/Report/Conference proceedingChapter

26 Scopus citations


Cysteine proteases have been discovered in various bloodfeeding ectoparasites. Here, we assemble the available information about the function of these peptidases and reveal their role in hematophagy and parasite development. While most of the data shed light on key proteolytic events that play a role in arthropod physiology, we also report on the association of cysteine proteases with arthropod vectorial capacity. With emphasis on ticks, specifically Ixodes ricinus, we finally propose a model about the contribution of cysteine peptidases to blood digestion and how their concerted action with other tick midgut proteases leads to the absorbance of nutrients by the midgut epithelial cells.

Original languageEnglish (US)
Title of host publicationCysteine Proteases of Pathogenic Organisms
EditorsMark Robinson, John Dalton
Number of pages15
StatePublished - 2011
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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