Cyclophosphamide for the treatment of progressive low-grade astrocytoma: A Pediatric Oncology Group Phase II study

Richard P. Kadota, Larry E. Kun, James W. Langston, Peter C. Burger, Michael E. Cohen, Donald H. Mahoney, Andrew W. Walter, John H. Rodman, Andrew Parent, Edward Buckley, James L. Kepner, Henry S. Friedman

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Purpose: Results of a phase II trial of cyclophosphamide (CPM) for children with progressive low-grade astrocytoma are reported. Patients and Methods: Fifteen patients with a median age of 39 months (range, 2 to 71) were included in this study. The tumors of 11 children were located in the optic pathway, hypothalamus, or thalamus. Four courses of intravenous CPM 1.2 g/m2 were administered every 3 weeks during the upfront window portion of this protocol. Subsequently, chemotherapy was to continue with CPM, vincristine, and carboplatin for 2 years. Results: By study design, the first 14 patients were centrally reviewed after completion of the initial 4 CPM courses. Toxicity was primarily hematologic. One patients had a complete response, 8 had stable disease, and 5 had progressive disease (PD). The excessive number of children with PD prompted study closure. Conclusion: CPM as used in this protocol showed insufficient activity against astrocytoma to justify further patient accrual.

Original languageEnglish (US)
Pages (from-to)198-202
Number of pages5
JournalJournal of Pediatric Hematology/Oncology
Issue number3
StatePublished - May 1 1999
Externally publishedYes


  • Astrocytoma
  • Cyclophosphamide
  • Optic glioma
  • Pediatric brain tumor
  • Phase II study

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology


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