Abstract
Cyclic AMP phosphodiesterase (EC 3.1.4.17) activity was characterized in an extract of C. albicans. The enzyme showed a pH optimum at 7.5 and was not activated by imidazole or inhibited by theophylline or caffeine. Phosphodiesterase activity of Candida was stimulated by Ca++ and Mg++ and the apparent Km values for cAMP were 4.2 and 250 μM. The enzyme activity was increased during germination and dropped steadily during the pseudohyphal stage of morphogenesis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 47-53 |
| Number of pages | 7 |
| Journal | Microbios Letters |
| Volume | 3 |
| Issue number | 9 |
| State | Published - Dec 1 1976 |
ASJC Scopus subject areas
- Microbiology
- Immunology
- Hematology
- General Biochemistry, Genetics and Molecular Biology
- Pharmacology