Cutting edge: STAT1 and T-bet play distinct roles in determining outcome of visceral leishmaniasis caused by Leishmania donovani

Lucia E. Rosas; Heidi M. Snider; Joseph Barbi; Anjali A. Satoskar; Geanncarlo Lugo-Villarino; Tracy Keiser; Tracy Papenfuss; Joan E. Durbin; Danuta Radzioch; Laurie H. Glimcher; Abhay R. Satoskar

doi:10.4049/jimmunol.177.1.22

Cutting edge: STAT1 and T-bet play distinct roles in determining outcome of visceral leishmaniasis caused by Leishmania donovani

Lucia E. Rosas, Heidi M. Snider, Joseph Barbi, Anjali A. Satoskar, Geanncarlo Lugo-Villarino, Tracy Keiser, Tracy Papenfuss, Joan E. Durbin, Danuta Radzioch, Laurie H. Glimcher, Abhay R. Satoskar

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

T-bet and STAT1 regulate IFN-γ gene transcription in CD4⁺ T cells, which mediate protection against Leishmania. Here we show that T-bet and STAT1 are required for the induction of an efficient Th1 response during Leishmania donovani infection, but they play distinct roles in determining disease outcome. Both STAT1^-/- and T-bet^-/- mice failed to mount a Th1 response, but STAT1^-/- mice were highly resistant to L. donovani and developed less immunopathology, whereas T-bet^-/- mice were highly susceptible and eventually developed liver inflammation. Adoptive cell transfer studies showed that RAG2^-/- recipients receiving STA1^+/+ or STAT1^-/- T cells developed comparable liver pathology, but those receiving STAT1^-/- T cells were significantly more susceptible to infection. These unexpected findings reveal distinct roles for T-bet and STAT1 in mediating host immunity and liver pathology during visceral leishmaniasis.

Original language	English (US)
Pages (from-to)	22-25
Number of pages	4
Journal	Journal of Immunology
Volume	177
Issue number	1
DOIs	https://doi.org/10.4049/jimmunol.177.1.22
State	Published - Jul 1 2006
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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Rosas, L. E., Snider, H. M., Barbi, J., Satoskar, A. A., Lugo-Villarino, G., Keiser, T., Papenfuss, T., Durbin, J. E., Radzioch, D., Glimcher, L. H., & Satoskar, A. R. (2006). Cutting edge: STAT1 and T-bet play distinct roles in determining outcome of visceral leishmaniasis caused by Leishmania donovani. Journal of Immunology, 177(1), 22-25. https://doi.org/10.4049/jimmunol.177.1.22

Rosas, LE, Snider, HM, Barbi, J, Satoskar, AA, Lugo-Villarino, G, Keiser, T, Papenfuss, T, Durbin, JE, Radzioch, D, Glimcher, LH & Satoskar, AR 2006, 'Cutting edge: STAT1 and T-bet play distinct roles in determining outcome of visceral leishmaniasis caused by Leishmania donovani', Journal of Immunology, vol. 177, no. 1, pp. 22-25. https://doi.org/10.4049/jimmunol.177.1.22

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abstract = "T-bet and STAT1 regulate IFN-γ gene transcription in CD4+ T cells, which mediate protection against Leishmania. Here we show that T-bet and STAT1 are required for the induction of an efficient Th1 response during Leishmania donovani infection, but they play distinct roles in determining disease outcome. Both STAT1-/- and T-bet-/- mice failed to mount a Th1 response, but STAT1-/- mice were highly resistant to L. donovani and developed less immunopathology, whereas T-bet-/- mice were highly susceptible and eventually developed liver inflammation. Adoptive cell transfer studies showed that RAG2-/- recipients receiving STA1+/+ or STAT1-/- T cells developed comparable liver pathology, but those receiving STAT1-/- T cells were significantly more susceptible to infection. These unexpected findings reveal distinct roles for T-bet and STAT1 in mediating host immunity and liver pathology during visceral leishmaniasis.",

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Cutting edge: STAT1 and T-bet play distinct roles in determining outcome of visceral leishmaniasis caused by Leishmania donovani

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