Cutaneous Toxicities of PI3K Inhibitors: A Series of Two Cases and Review of the Literature

Simran A. Chadha, Jennifer L. Shastry, Joel C. Sunshine, Jennifer Choi, Lauren Guggina

Research output: Contribution to journalReview articlepeer-review


Phosphoinositide 3-kinase (PI3K) inhibitors are a class of antineoplastic agents currently approved for the treatment of multiple hematologic malignancies and breast cancer. These medications have specific molecular targets to limit toxicity; however, cutaneous adverse effects are frequently reported and can require cessation of therapy. Morbilliform, eczematous, psoriasiform, and pityriasis rubra pilaris-like eruptions are most common, though exfoliative dermatitis and Stevens-Johnson syndrome/toxic epidermal necrolysis have also been reported. We highlight two cases of photo-accentuated skin reactions to duvelisib, a p110-δ and p110-γ isoform inhibitor. Both cases required oral corticosteroids and interruption of therapy for definitive management due to severity. While one patient was able to tolerate re-challenge with duvelisib and continue on therapy, both patients experienced recurrence of cutaneous eruptions with repeat exposure, establishing a notable temporal correlation. Thus, these cases contribute a novel presentation of adverse reactions to PI3K inhibitors to existing literature.

Original languageEnglish (US)
Pages (from-to)585-590
Number of pages6
JournalSKIN: Journal of Cutaneous Medicine
Issue number6
StatePublished - Nov 15 2020
Externally publishedYes


  • adverse effect
  • duvelisib
  • Phosphoinositide 3-kinase inhibitors
  • photo-accentuated
  • pityriasis rubra pilaris

ASJC Scopus subject areas

  • Dermatology


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