Cutaneous Cancer Biology

Alok R. Khandelwal; Kristen A. Echanique; Maie St. John; Cherie Ann Nathan

doi:10.1016/j.otc.2020.11.002

Cutaneous Cancer Biology

Alok R. Khandelwal
, Kristen A. Echanique
, Maie St. John
, Cherie Ann Nathan

Research output: Contribution to journal › Review article › peer-review

Abstract

There has been a drastic increase in the incidence of nonmelanoma (NMSC), including squamous, basal cell, and melanoma skin cancers worldwide. Most cases of skin cancer can be treated effectively with surgery; fewer than 10% of cases are advanced and may require additional therapies. A better understanding of the biology of skin cancer will help contribute to better prognostic information and identification of possible new therapeutic targets. Herein, the authors review the biology and pathogenesis of both NMSC and melanoma, focusing on critical cell signaling pathways mediating the disease and current therapeutic strategies targeted to underlying genetic pathways.

Original language	English (US)
Pages (from-to)	259-269
Number of pages	11
Journal	Otolaryngologic Clinics of North America
Volume	54
Issue number	2
DOIs	https://doi.org/10.1016/j.otc.2020.11.002
State	Published - Apr 2021
Externally published	Yes

Keywords

Basal cell carcinoma
Cutaneous skin cancer
Head and neck cancer
Melanoma
Merkel cell carcinoma
Squamous cell carcinoma

ASJC Scopus subject areas

Otorhinolaryngology

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10.1016/j.otc.2020.11.002

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@article{38939bf81ac44fb7a4fd42f553e804bf,

title = "Cutaneous Cancer Biology",

abstract = "There has been a drastic increase in the incidence of nonmelanoma (NMSC), including squamous, basal cell, and melanoma skin cancers worldwide. Most cases of skin cancer can be treated effectively with surgery; fewer than 10\% of cases are advanced and may require additional therapies. A better understanding of the biology of skin cancer will help contribute to better prognostic information and identification of possible new therapeutic targets. Herein, the authors review the biology and pathogenesis of both NMSC and melanoma, focusing on critical cell signaling pathways mediating the disease and current therapeutic strategies targeted to underlying genetic pathways.",

keywords = "Basal cell carcinoma, Cutaneous skin cancer, Head and neck cancer, Melanoma, Merkel cell carcinoma, Squamous cell carcinoma",

author = "Khandelwal, \{Alok R.\} and Echanique, \{Kristen A.\} and \{St. John\}, Maie and Nathan, \{Cherie Ann\}",

note = "Publisher Copyright: {\textcopyright} 2020",

year = "2021",

month = apr,

doi = "10.1016/j.otc.2020.11.002",

language = "English (US)",

volume = "54",

pages = "259--269",

journal = "Otolaryngologic Clinics of North America",

issn = "0030-6665",

publisher = "W.B. Saunders",

number = "2",

}

TY - JOUR

T1 - Cutaneous Cancer Biology

AU - Khandelwal, Alok R.

AU - Echanique, Kristen A.

AU - St. John, Maie

AU - Nathan, Cherie Ann

PY - 2021/4

Y1 - 2021/4

N2 - There has been a drastic increase in the incidence of nonmelanoma (NMSC), including squamous, basal cell, and melanoma skin cancers worldwide. Most cases of skin cancer can be treated effectively with surgery; fewer than 10% of cases are advanced and may require additional therapies. A better understanding of the biology of skin cancer will help contribute to better prognostic information and identification of possible new therapeutic targets. Herein, the authors review the biology and pathogenesis of both NMSC and melanoma, focusing on critical cell signaling pathways mediating the disease and current therapeutic strategies targeted to underlying genetic pathways.

AB - There has been a drastic increase in the incidence of nonmelanoma (NMSC), including squamous, basal cell, and melanoma skin cancers worldwide. Most cases of skin cancer can be treated effectively with surgery; fewer than 10% of cases are advanced and may require additional therapies. A better understanding of the biology of skin cancer will help contribute to better prognostic information and identification of possible new therapeutic targets. Herein, the authors review the biology and pathogenesis of both NMSC and melanoma, focusing on critical cell signaling pathways mediating the disease and current therapeutic strategies targeted to underlying genetic pathways.

KW - Basal cell carcinoma

KW - Cutaneous skin cancer

KW - Head and neck cancer

KW - Melanoma

KW - Merkel cell carcinoma

KW - Squamous cell carcinoma

UR - https://www.scopus.com/pages/publications/85100969042

UR - https://www.scopus.com/pages/publications/85100969042#tab=citedBy

U2 - 10.1016/j.otc.2020.11.002

DO - 10.1016/j.otc.2020.11.002

M3 - Review article

C2 - 33583599

AN - SCOPUS:85100969042

SN - 0030-6665

VL - 54

SP - 259

EP - 269

JO - Otolaryngologic Clinics of North America

JF - Otolaryngologic Clinics of North America

IS - 2

ER -

Cutaneous Cancer Biology

Abstract

Keywords

ASJC Scopus subject areas

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