TY - JOUR
T1 - Customized adherence enhancement for individuals with bipolar disorder receiving antipsychotic therapy
AU - Sajatovic, Martha
AU - Levin, Jennifer
AU - Tatsuoka, Curtis
AU - Micula-Gondek, Weronika
AU - Williams, Tiffany D.
AU - Bialko, Christopher S.
AU - Cassidy, Kristin A.
PY - 2012/2/1
Y1 - 2012/2/1
N2 - Objective: A three-month prospective trial of a psychosocial intervention-customized adherence enhancement (CAE)-was conducted with 43 medicationnonadherent individuals with bipolar disorder. Methods: CAE modules were administered as indicated by a screen that identifies reasons for nonadherence. The primary outcome was change in adherence to mood-stabilizing medications as measured by the Tablet Routines Questionnaire and pill counts. Secondary outcomes included change in symptoms, measured by the Hamilton Rating Scale for Depression (HAM-D), Young Mania Rating Scale (YMRS), and Brief Psychiatric Rating Scale (BPRS). Results: Participants completed 76% of sessions. Dropout at three months was 13 (30%). Adherence improved from a baseline mean±SD of 34%±27% of tablets missed in the past month to only 10%±15% (p<.001). BPRS, HAM-D, and YMRS scores all indicated significant improvement at three-month follow-up (p<.05). Conclusions: Although conclusions must be tempered by the uncontrolled design, CAE appeared to be well accepted and was associated with improvements in adherence, symptoms, and functioning.
AB - Objective: A three-month prospective trial of a psychosocial intervention-customized adherence enhancement (CAE)-was conducted with 43 medicationnonadherent individuals with bipolar disorder. Methods: CAE modules were administered as indicated by a screen that identifies reasons for nonadherence. The primary outcome was change in adherence to mood-stabilizing medications as measured by the Tablet Routines Questionnaire and pill counts. Secondary outcomes included change in symptoms, measured by the Hamilton Rating Scale for Depression (HAM-D), Young Mania Rating Scale (YMRS), and Brief Psychiatric Rating Scale (BPRS). Results: Participants completed 76% of sessions. Dropout at three months was 13 (30%). Adherence improved from a baseline mean±SD of 34%±27% of tablets missed in the past month to only 10%±15% (p<.001). BPRS, HAM-D, and YMRS scores all indicated significant improvement at three-month follow-up (p<.05). Conclusions: Although conclusions must be tempered by the uncontrolled design, CAE appeared to be well accepted and was associated with improvements in adherence, symptoms, and functioning.
UR - http://www.scopus.com/inward/record.url?scp=84857664821&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84857664821&partnerID=8YFLogxK
U2 - 10.1176/appi.ps.201100133
DO - 10.1176/appi.ps.201100133
M3 - Article
C2 - 22302337
AN - SCOPUS:84857664821
SN - 1075-2730
VL - 63
SP - 176
EP - 178
JO - Psychiatric Services
JF - Psychiatric Services
IS - 2
ER -