Customized adherence enhancement for individuals with bipolar disorder receiving antipsychotic therapy

Martha Sajatovic, Jennifer Levin, Curtis Tatsuoka, Weronika Micula-Gondek, Tiffany D. Williams, Christopher S. Bialko, Kristin A. Cassidy

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Objective: A three-month prospective trial of a psychosocial intervention-customized adherence enhancement (CAE)-was conducted with 43 medicationnonadherent individuals with bipolar disorder. Methods: CAE modules were administered as indicated by a screen that identifies reasons for nonadherence. The primary outcome was change in adherence to mood-stabilizing medications as measured by the Tablet Routines Questionnaire and pill counts. Secondary outcomes included change in symptoms, measured by the Hamilton Rating Scale for Depression (HAM-D), Young Mania Rating Scale (YMRS), and Brief Psychiatric Rating Scale (BPRS). Results: Participants completed 76% of sessions. Dropout at three months was 13 (30%). Adherence improved from a baseline mean±SD of 34%±27% of tablets missed in the past month to only 10%±15% (p<.001). BPRS, HAM-D, and YMRS scores all indicated significant improvement at three-month follow-up (p<.05). Conclusions: Although conclusions must be tempered by the uncontrolled design, CAE appeared to be well accepted and was associated with improvements in adherence, symptoms, and functioning.

Original languageEnglish (US)
Pages (from-to)176-178
Number of pages3
JournalPsychiatric Services
Issue number2
StatePublished - Feb 1 2012
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health


Dive into the research topics of 'Customized adherence enhancement for individuals with bipolar disorder receiving antipsychotic therapy'. Together they form a unique fingerprint.

Cite this