Curved-field optical coherence tomography: Large-field imaging of human corneal cells and nerves

Viacheslav Mazlin, Kristina Irsch, Michel Paques, Jose Alain Sahel, Mathias Fink, Claude A. Boccara

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Cell-resolution optical imaging methods, such as confocal microscopy and full-field optical coherence tomography, capture flat optical sections of the sample. If the sample is curved, the optical field sections through several sample layers, and the view of each layer is reduced. Here we present curved-field optical coherence tomography, capable of capturing optical sections of arbitrary curvature. We test the device on a challenging task of imaging the human cornea in vivo and achieve a 10× larger viewing area comparing to the clinical state-of-the-art. This enables more precise cell and nerve counts, opening a path to improved monitoring of corneal and general health conditions (e.g., diabetes). The method is non-contact, compact, and works in a single fast shot (3.5 ms), making it readily available for use in optical research and clinical practice.

Original languageEnglish (US)
Pages (from-to)872-880
Number of pages9
Issue number8
StatePublished - Aug 2020
Externally publishedYes

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics


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