Abstract
As our understanding of HNSCC increases so has biomarker development. HPV16 integration is a significant marker of favorable prognosis and response to therapy for HNSCC. EGFR-amplification and overexpression is a poor-prognostic indicator. For premalignant lesions, LOH of 3p&9p21 loci confers an elevated risk of malignant transformation. As molecular targets are identified, these will be candidates for biomarkers for detection, diagnosis, prognosis, and therapy. Validation of these biomarkers requires demonstration of independence of significance beyond known biomarkers.
Original language | English (US) |
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Pages (from-to) | 640-643 |
Number of pages | 4 |
Journal | Journal of Surgical Oncology |
Volume | 97 |
Issue number | 8 |
DOIs | |
State | Published - Jun 15 2008 |
Keywords
- EGFR
- HNSCC
- HPV
- LOH
- Squamous cell carcinoma
ASJC Scopus subject areas
- Surgery
- Oncology