Current management of a thyroid nodule

R. P. Tufano, S. I. Noureldine, E. H. Kandil

Research output: Contribution to journalArticlepeer-review


Thyroid nodules are commonly encountered by physicians from a diverse range of specialties and are becoming increasingly prevalent. The clinical importance of thyroid nodules rests with the need to exclude thyroid malignancy. We used current evidence and guidelines to discuss management options. Ultrasonography is often the first effective imaging modality employed to evaluate a thyroid nodule. Investigation should also include careful history and examination and thyroid function tests. Low serum thyroid stimulating Fiorinone concentration indicates overt or subclinical hyperthyroidism, increasing the possibility that the nodule is hot or autonomous and requires radionuclide scan for assessment. Ultrasound guided fine needle aspiration biopsy provides direct specific information about the cytology of the nodule. Applying genetic markers to FNAB specimens offers more improved diagnostic accuracy. Thyroid nodules diagnosed as benign require follow-up with serial ultrasound examinations. Detailed management of indeterminate lesions is also discussed. Differentiated thyroid cancer (DTC) comprises the vast majority of ali thyroid cancers. The primary mode of therapy for malignant nodules is surgical intervention, with total thyroidectomy. Tailored surgical treatment according to the extent of the disease is also discussed. Regional lymph node metastases are present at the time of diagnosis in 20- 90% of patients with DTC, increasing the rates of mortality. Suspicious lymph nodes should undergo FNAB. For positive findings, appropriate additional compartment lymph node dissection should be preformed. The role of radioiodine therapy is discussed in our article.

Original languageEnglish (US)
Pages (from-to)71-87
Number of pages17
Issue number3
StatePublished - Sep 1 2011


  • Thyroid neoplasms
  • Thyroid nodule
  • Thyroidectomy

ASJC Scopus subject areas

  • Otorhinolaryngology


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