Current management challenges in HIV: Antiretroviral resistance

Daniel R. Kuritzkes, Brian A. Boyle, Joel E. Gallant, Kathleen E. Squires, Andrew Zolopa

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Emergence of drug-resistant viral variants is a major reason why HIV-infected patients experience viral rebound during antiretroviral therapy. Although combination antiretroviral therapy substantially inhibits viral replication, replication-competent mutant virus remains. In addition, it is now clear that virologic failure is not necessarily caused by failure of all drugs in a regimen. The use of resistance-testing data can assist in understanding the reasons for failure of antiretroviral therapy. However, there is a need for additional trials to better define the role resistance testing may play in developing management approaches to mitigate or minimize emergence of resistant HIV.

Original languageEnglish (US)
Pages (from-to)133-135+138
JournalThe AIDS reader
Issue number3
StatePublished - Mar 1 2003


  • Antiretroviral therapy
  • Drug resistance
  • Genotype
  • Phenotype

ASJC Scopus subject areas

  • Virology
  • Medicine(all)


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