Current HIV/SIV Reservoir Assays for Preclinical and Clinical Applications: Recommendations from the Experts 2022 NIAID Workshop Summary

Brigitte E. Sanders-Beer, Nancie M. Archin, Zabrina L. Brumme, Michael P. Busch, Claire Deleage, Una O’Doherty, Stephen H. Hughes, Keith R. Jerome, R. Brad Jones, Jonathan Karn, Mary F. Kearney, Brandon F. Keele, Deanna A. Kulpa, Gregory M. Laird, Jonathan Z. Li, Mathias D. Lichterfeld, Michel C. Nussenzweig, Deborah Persaud, Steven A. Yukl, Robert F. SilicianoJohn W. Mellors

Research output: Contribution to journalArticlepeer-review

Abstract

Since the first HIV-cured person was reported in 2009, a strong interest in developing highly sensitive HIV and SIV reservoir assays has emerged. In particular, the question arose about the comparative value of state-of-theart assays to measure and characterize the HIV reservoir, and how these assays can be applied to accurately detect changes in the reservoir during efforts to develop a cure for HIV infection. Second, it is important to consider the impact on the outcome of clinical trials if these relatively new HIV reservoir assays are incorporated into clinical trial endpoints and/or used for clinical decision-making. To understand the advantages and limitations and the regulatory implications of HIV reservoir assays, the National Institute of Allergy and Infectious Diseases (NIAID) sponsored and convened a meeting on September 16, 2022, to discuss the state of knowledge concerning these questions and best practices for selecting HIV reservoir assays for a particular research question or clinical trial protocol.

Original languageEnglish (US)
Pages (from-to)7-21
Number of pages15
JournalAIDS research and human retroviruses
Volume40
Issue number1
DOIs
StatePublished - Jan 1 2024

Keywords

  • HIV
  • SIV
  • assays
  • clinical trials
  • reservoir

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology
  • Immunology

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