@article{d8eacf5887074dd18d29b01c216f8bfa,
title = "Current approaches to potential amyloid-based Alzheimer's disease therapies: Defeating dementia",
abstract = "Alzheimer's disease (AD) is a progressive neurodegenerative disorder, accounting for 700000 people in the UK and 25 million people worldwide with dementia1. Already licensed treatments, cholinesterase inhibitors and an NMDA (N-methyl-d-aspartate) receptor antagonist, confer important symptomatic benefits2, but at present, there are no treatments that can delay or halt the disease progression. This review outlines one of the main mechanisms currently thought to underpin the development of AD, and the treatments that are being developed based upon it.",
keywords = "Alzheimer's disease, Cholinesterase inhibitors, Neurotransmitters, Statins, β-amyloid plaque, β-secretase, γ-secretase",
author = "Ayesha Khan and Clive Ballard",
note = "Funding Information: Ayesha Khan is scientific liaison officer for the Alzheimer{\textquoteright}s Society and facilitates the award winning consumer-led Quality Research in Dementia grants funding programme. She was previously a scientific researcher examining the biological chemistry of beta amyloid and other dementia-related peptides at Keele University as well as the physical chemistry of the neurotransmitter molecule nitric oxide at King{\textquoteright}s College London. email: AKhan@alzheimers.org.uk Clive Ballard is director of research for the Alzheimer{\textquoteright}s Society and Professor of Age Related Disorders at Kings College London/Institute of Psychiatry. He was previously Professor of Old Age Psychiatry at the University of Newcastle. Ongoing programmes of research include scientific studies and clinical trials in the areas of vascular dementia, dementia with Lewy bodies, psychiatric and behavioural symptoms in people with dementia and dementia in Down{\textquoteright}s syndrome. email: clive.ballard@kcl.ac.uk",
year = "2008",
month = oct,
doi = "10.1042/bio03005014",
language = "English (US)",
volume = "30",
pages = "14--17",
journal = "Biochemist",
issn = "0954-982X",
publisher = "Portland Press Ltd.",
number = "5",
}