Current approach to pediatric soft tissue sarcomas

Melinda S. Merchant, Crystal L. Mackall

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


The development of a new soft tissue lesion in an otherwise healthy child, adolescent, or young adult can present many challenges for pediatric or medical oncology teams. Although uncommon, the diagnosis of a soft tissue malignancy should always be considered in the differential diagnosis of persistent pain, even if no mass is palpable. The definitive diagnosis and treatment of a soft tissue mass is aided by timely scans, appropriate biopsy for anatomic and molecular pathology, and a treatment approach guided by the specific diagnosis. Because pediatric soft tissue sarcomas are rare, cooperative groups play a crucial role in defining the standard of care through retrospective series and well-designed prospective clinical trials. Enrollment of newly diagnosed patients in clinical studies should be encouraged in order to continue to improve outcomes and understanding of these rare tumors. This review focuses on the current recommendations for management of sarcomas that typically occur in the soft tissues of pediatric and young adult patients.

Original languageEnglish (US)
Pages (from-to)1139-1153
Number of pages15
Issue number11
StatePublished - 2009
Externally publishedYes


  • Chemotherapy
  • Ewing's sarcoma
  • Pediatric malignancy
  • Sarcoma
  • Soft tissue
  • Synovial sarcoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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