@inbook{8acb69fd43c9496b9a38136a11095250,
title = "Current and emerging therapeutic strategies for perianal fistula in Crohn's disease patients",
abstract = "The long-term remission rates achieved with current treatment options for Crohn's disease with perianal fistula (CD-PAF)—including antibiotics, biologics, immunomodulators, and Janus kinase inhibitors, often combined with advanced surgical interventions—remain unsatisfactory. This chapter explores several innovative biomaterials-based solutions, such as plugs, adhesives, fillers, and stem cell-based therapies. The key approaches and treatment outcomes of these advanced therapies are examined, focusing on their ability to modulate the immune response, promote tissue healing, and improve patient outcomes. Additionally, the chapter discusses future directions, including the optimization of biomaterial designs, enhancement of delivery and retention of regenerative therapies, and a deeper understanding of the underlying mechanisms of healing.",
keywords = "Biomaterials, Crohn's disease, Perianal fistula, Stem cell-based therapies, Tissue healing",
author = "Kailei Ding and Jiayuan Kong and Ling Li and Selaru, {Florin M.} and Alyssa Parian and Mao, {Hai Quan}",
note = "Publisher Copyright: {\textcopyright} 2024",
year = "2024",
month = jan,
doi = "10.1016/bs.apha.2024.10.013",
language = "English (US)",
isbn = "9780443313585",
series = "Advances in Pharmacology",
publisher = "Academic Press Inc.",
pages = "159--182",
editor = "Selaru, {Florin M.} and Peters, {Diane E.}",
booktitle = "Emerging Therapeutic Targets and Drug Delivery Approaches in IBD",
}