Current and emerging therapeutic strategies for perianal fistula in Crohn's disease patients

Kailei Ding, Jiayuan Kong, Ling Li, Florin M. Selaru, Alyssa Parian, Hai Quan Mao

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The long-term remission rates achieved with current treatment options for Crohn's disease with perianal fistula (CD-PAF)—including antibiotics, biologics, immunomodulators, and Janus kinase inhibitors, often combined with advanced surgical interventions—remain unsatisfactory. This chapter explores several innovative biomaterials-based solutions, such as plugs, adhesives, fillers, and stem cell-based therapies. The key approaches and treatment outcomes of these advanced therapies are examined, focusing on their ability to modulate the immune response, promote tissue healing, and improve patient outcomes. Additionally, the chapter discusses future directions, including the optimization of biomaterial designs, enhancement of delivery and retention of regenerative therapies, and a deeper understanding of the underlying mechanisms of healing.

Original languageEnglish (US)
Title of host publicationEmerging Therapeutic Targets and Drug Delivery Approaches in IBD
EditorsFlorin M. Selaru, Diane E. Peters
PublisherAcademic Press Inc.
Pages159-182
Number of pages24
ISBN (Print)9780443313585
DOIs
StatePublished - Jan 2024

Publication series

NameAdvances in Pharmacology
Volume101
ISSN (Print)1054-3589
ISSN (Electronic)1557-8925

Keywords

  • Biomaterials
  • Crohn's disease
  • Perianal fistula
  • Stem cell-based therapies
  • Tissue healing

ASJC Scopus subject areas

  • Pharmacology

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