Current and Emerging Imaging Techniques for Neurofibromatosis Type 1–Associated Cutaneous Neurofibromas

Yingjoy Li; Jaishri O. Blakeley; Ina Ly; Yemima Berman; Jonathan Lau; Pierre Wolkenstein; Christina Bergqvist; Wangcun Jia; Thomas E. Milner; Nitesh Katta; Anthony J. Durkin; Gordon T. Kennedy; Rebecca Rowland; Carlos G. Romo; Jane Fleming; Kristen M. Kelly

doi:10.1016/j.jid.2023.03.1681

Current and Emerging Imaging Techniques for Neurofibromatosis Type 1–Associated Cutaneous Neurofibromas

Yingjoy Li, Jaishri O. Blakeley, Ina Ly, Yemima Berman, Jonathan Lau, Pierre Wolkenstein, Christina Bergqvist, Wangcun Jia, Thomas E. Milner, Nitesh Katta, Anthony J. Durkin, Gordon T. Kennedy, Rebecca Rowland, Carlos G. Romo, Jane Fleming, Kristen M. Kelly

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

A consistent set of measurement techniques must be applied to reliably and reproducibly evaluate the efficacy of treatments for cutaneous neurofibromas (cNFs) in people with neurofibromatosis type 1 (NF1). cNFs are neurocutaneous tumors that are the most common tumor in people with NF1 and represent an area of unmet clinical need. This review presents the available data regarding approaches in use or development to identify, measure, and track cNFs, including calipers, digital imaging, and high-frequency ultrasound sonography. We also describe emerging technologies such as spatial frequency domain imaging and the application of imaging modalities such as optical coherence tomography that may enable the detection of early cNFs and prevention of tumor-associated morbidity.

Original language	English (US)
Pages (from-to)	1397-1405
Number of pages	9
Journal	Journal of Investigative Dermatology
Volume	143
Issue number	8
DOIs	https://doi.org/10.1016/j.jid.2023.03.1681
State	Published - Aug 2023

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Dermatology
Cell Biology

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Li, Y., Blakeley, J. O., Ly, I., Berman, Y., Lau, J., Wolkenstein, P., Bergqvist, C., Jia, W., Milner, T. E., Katta, N., Durkin, A. J., Kennedy, G. T., Rowland, R., Romo, C. G., Fleming, J., & Kelly, K. M. (2023). Current and Emerging Imaging Techniques for Neurofibromatosis Type 1–Associated Cutaneous Neurofibromas. Journal of Investigative Dermatology, 143(8), 1397-1405. https://doi.org/10.1016/j.jid.2023.03.1681

Li, Y, Blakeley, JO, Ly, I, Berman, Y, Lau, J, Wolkenstein, P, Bergqvist, C, Jia, W, Milner, TE, Katta, N, Durkin, AJ, Kennedy, GT, Rowland, R, Romo, CG, Fleming, J & Kelly, KM 2023, 'Current and Emerging Imaging Techniques for Neurofibromatosis Type 1–Associated Cutaneous Neurofibromas', Journal of Investigative Dermatology, vol. 143, no. 8, pp. 1397-1405. https://doi.org/10.1016/j.jid.2023.03.1681

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title = "Current and Emerging Imaging Techniques for Neurofibromatosis Type 1–Associated Cutaneous Neurofibromas",

abstract = "A consistent set of measurement techniques must be applied to reliably and reproducibly evaluate the efficacy of treatments for cutaneous neurofibromas (cNFs) in people with neurofibromatosis type 1 (NF1). cNFs are neurocutaneous tumors that are the most common tumor in people with NF1 and represent an area of unmet clinical need. This review presents the available data regarding approaches in use or development to identify, measure, and track cNFs, including calipers, digital imaging, and high-frequency ultrasound sonography. We also describe emerging technologies such as spatial frequency domain imaging and the application of imaging modalities such as optical coherence tomography that may enable the detection of early cNFs and prevention of tumor-associated morbidity.",

author = "Yingjoy Li and Blakeley, {Jaishri O.} and Ina Ly and Yemima Berman and Jonathan Lau and Pierre Wolkenstein and Christina Bergqvist and Wangcun Jia and Milner, {Thomas E.} and Nitesh Katta and Durkin, {Anthony J.} and Kennedy, {Gordon T.} and Rebecca Rowland and Romo, {Carlos G.} and Jane Fleming and Kelly, {Kristen M.}",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors",

year = "2023",

month = aug,

doi = "10.1016/j.jid.2023.03.1681",

language = "English (US)",

volume = "143",

pages = "1397--1405",

journal = "Journal of Investigative Dermatology",

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T1 - Current and Emerging Imaging Techniques for Neurofibromatosis Type 1–Associated Cutaneous Neurofibromas

AU - Li, Yingjoy

AU - Blakeley, Jaishri O.

AU - Ly, Ina

AU - Berman, Yemima

AU - Lau, Jonathan

AU - Wolkenstein, Pierre

AU - Bergqvist, Christina

AU - Jia, Wangcun

AU - Milner, Thomas E.

AU - Katta, Nitesh

AU - Durkin, Anthony J.

AU - Kennedy, Gordon T.

AU - Rowland, Rebecca

AU - Romo, Carlos G.

AU - Fleming, Jane

AU - Kelly, Kristen M.

PY - 2023/8

Y1 - 2023/8

N2 - A consistent set of measurement techniques must be applied to reliably and reproducibly evaluate the efficacy of treatments for cutaneous neurofibromas (cNFs) in people with neurofibromatosis type 1 (NF1). cNFs are neurocutaneous tumors that are the most common tumor in people with NF1 and represent an area of unmet clinical need. This review presents the available data regarding approaches in use or development to identify, measure, and track cNFs, including calipers, digital imaging, and high-frequency ultrasound sonography. We also describe emerging technologies such as spatial frequency domain imaging and the application of imaging modalities such as optical coherence tomography that may enable the detection of early cNFs and prevention of tumor-associated morbidity.

AB - A consistent set of measurement techniques must be applied to reliably and reproducibly evaluate the efficacy of treatments for cutaneous neurofibromas (cNFs) in people with neurofibromatosis type 1 (NF1). cNFs are neurocutaneous tumors that are the most common tumor in people with NF1 and represent an area of unmet clinical need. This review presents the available data regarding approaches in use or development to identify, measure, and track cNFs, including calipers, digital imaging, and high-frequency ultrasound sonography. We also describe emerging technologies such as spatial frequency domain imaging and the application of imaging modalities such as optical coherence tomography that may enable the detection of early cNFs and prevention of tumor-associated morbidity.

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DO - 10.1016/j.jid.2023.03.1681

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AN - SCOPUS:85162925057

SN - 0022-202X

VL - 143

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JO - Journal of Investigative Dermatology

JF - Journal of Investigative Dermatology

IS - 8

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Current and Emerging Imaging Techniques for Neurofibromatosis Type 1–Associated Cutaneous Neurofibromas

Abstract

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