Cumplimiento en España de la norma de prescribir cuatro fármacos en la fase intensiva del tratamiento estándar de la tuberculosis

Grupo de Trabajo del Programa Integrado de Investigación en Tuberculosis (PIITB)

doi:10.1016/j.arbr.2016.03.009

Cumplimiento en España de la norma de prescribir cuatro fármacos en la fase intensiva del tratamiento estándar de la tuberculosis

Translated title of the contribution: Spanish Compliance With Guidelines for Prescribing Four Drugs in the Intensive Phase of Standard Tuberculosis Treatment

Grupo de Trabajo del Programa Integrado de Investigación en Tuberculosis (PIITB)

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Introduction: International and Spanish guidelines recommend a 4-drug regimen in the intensive treatment of tuberculosis (TB). The aim of our study was to determine if these recommendations are followed in Spain, and the factors associated with the use of 3 drugs (standard regimen without ethambutol). Methodology: Observational, multicenter, retrospective analysis of data from patients diagnosed with TB in practically all Spanish Autonomous Communities between 2007 and 2102. Factors associated with the use of 3 drugs were analyzed using logistic regression, and odds ratios (OR) and corresponding 95% confidence intervals (CI) were calculated. Results: A total of 3,189 patients were included, 1,413 (44.3%) of whom received 3 drugs. The percentage of 3-drug users among patients with positive sputum smear was 41.2%; among patients with resistance to at least 1 drug, 36.1%; among HIV-infected patients, 31.4%; and among immigrants, 24.8%. Factors associated with the use of 3 drugs were: female sex (OR = 1.18; CI: 1.00-1.39); native Spanish (OR = 3.09; CI: 2.58-3.70); retired (OR = 1.42; CI: 1.14-1.77); homeless (OR = 3.10; CI: 1.52-6.43); living alone (OR = 1.62; CI: 1.11-2.36); living in a family (OR = 1.97; CI: 1.48-2.65); seen by specialists in the region (OR = 1.37; CI: 1.10;1.70); no HIV infection (OR = 1.63; CI: 1.09-2.48); and negative sputum smear with positive culture (OR = 1.59; CI: 1.25-2.02). Conclusions: A large proportion of TB patients receive intensive treatment with 3 drugs. TB treatment recommendations should be followed, both in routine clinical practice and by the National Plan for Prevention and Control of Tuberculosis in Spain.

Translated title of the contribution	Spanish Compliance With Guidelines for Prescribing Four Drugs in the Intensive Phase of Standard Tuberculosis Treatment
Original language	Spanish
Pages (from-to)	262-268
Number of pages	7
Journal	Archivos de Bronconeumologia
Volume	52
Issue number	5
DOIs	https://doi.org/10.1016/j.arbr.2016.03.009
State	Published - May 1 2016

Keywords

Adherence
Guidelines
Treatment
Tuberculosis

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

Access to Document

10.1016/j.arbr.2016.03.009

Cite this

@article{9e12ccd67ca149e59d24bf5a2f5b024e,

title = "Cumplimiento en Espa{\~n}a de la norma de prescribir cuatro f{\'a}rmacos en la fase intensiva del tratamiento est{\'a}ndar de la tuberculosis",

abstract = "Introduction: International and Spanish guidelines recommend a 4-drug regimen in the intensive treatment of tuberculosis (TB). The aim of our study was to determine if these recommendations are followed in Spain, and the factors associated with the use of 3 drugs (standard regimen without ethambutol). Methodology: Observational, multicenter, retrospective analysis of data from patients diagnosed with TB in practically all Spanish Autonomous Communities between 2007 and 2102. Factors associated with the use of 3 drugs were analyzed using logistic regression, and odds ratios (OR) and corresponding 95% confidence intervals (CI) were calculated. Results: A total of 3,189 patients were included, 1,413 (44.3%) of whom received 3 drugs. The percentage of 3-drug users among patients with positive sputum smear was 41.2%; among patients with resistance to at least 1 drug, 36.1%; among HIV-infected patients, 31.4%; and among immigrants, 24.8%. Factors associated with the use of 3 drugs were: female sex (OR = 1.18; CI: 1.00-1.39); native Spanish (OR = 3.09; CI: 2.58-3.70); retired (OR = 1.42; CI: 1.14-1.77); homeless (OR = 3.10; CI: 1.52-6.43); living alone (OR = 1.62; CI: 1.11-2.36); living in a family (OR = 1.97; CI: 1.48-2.65); seen by specialists in the region (OR = 1.37; CI: 1.10;1.70); no HIV infection (OR = 1.63; CI: 1.09-2.48); and negative sputum smear with positive culture (OR = 1.59; CI: 1.25-2.02). Conclusions: A large proportion of TB patients receive intensive treatment with 3 drugs. TB treatment recommendations should be followed, both in routine clinical practice and by the National Plan for Prevention and Control of Tuberculosis in Spain.",

keywords = "Adherence, Guidelines, Treatment, Tuberculosis",

author = "{Grupo de Trabajo del Programa Integrado de Investigaci{\'o}n en Tuberculosis (PIITB)} and Garc{\'i}a-Garc{\'i}a, {Jos{\'e} Mar{\'i}a} and Teresa Rodrigo and Mart{\'i} Casals and Juan Ruiz-Manzano and Teresa Pascual-Pascual and Cayl{\`a}, {Joan A.} and R. Ag{\"u}ero and Alc{\'a}zar, {J. L.} and N. Altet and L. Altube and {{\'A}lvarez Navascu{\'e}s}, F. and L. Anibarro and M. Barr{\'o}n and P. Berm{\'u}dez and R. Blanquer and L. Border{\'i}as and A. Bustamante and Calpe, {J. L.} and Caminero, {J. A.} and F. Ca{\~n}as and F. Casas and X. Casas and E. Cases and R. Castrodeza and Cebri{\'a}n, {J. J.} and Ciruelos, {J. E.} and Delgado, {A. E.} and {de Souza}, {M. L.} and D. D{\'i}az and B. Fern{\'a}ndez and A. Fern{\'a}ndez and J. Gallardo and M. Gallego and Garc{\'i}aClemente, {M. M.} and C. Garc{\'i}a and Garc{\'i}a, {F. J.} and Garros, {F. J.} and Gull{\'o}n, {J. A.} and C. Hidalgo and M. Iglesias and G. Jim{\'e}nez and Jim{\'e}nez, {M. A.} and Kindelan, {J. M.} and J. Laparra and R. Lera and T. Lloret and M. Mar{\'i}n and Mart{\'i}nez, {J. T.} and E. Mart{\'i}nez and A. Mart{\'i}nez",

note = "Publisher Copyright: {\textcopyright} 2015 SEPAR.",

year = "2016",

month = may,

day = "1",

doi = "10.1016/j.arbr.2016.03.009",

language = "Spanish",

volume = "52",

pages = "262--268",

journal = "Archivos de Bronconeumologia",

issn = "0300-2896",

publisher = "Sociedad Espanola de Neumologia y Cirugia Toracica (SEPAR)",

number = "5",

}

TY - JOUR

T1 - Cumplimiento en España de la norma de prescribir cuatro fármacos en la fase intensiva del tratamiento estándar de la tuberculosis

AU - Grupo de Trabajo del Programa Integrado de Investigación en Tuberculosis (PIITB)

AU - García-García, José María

AU - Rodrigo, Teresa

AU - Casals, Martí

AU - Ruiz-Manzano, Juan

AU - Pascual-Pascual, Teresa

AU - Caylà, Joan A.

AU - Agüero, R.

AU - Alcázar, J. L.

AU - Altet, N.

AU - Altube, L.

AU - Álvarez Navascués, F.

AU - Anibarro, L.

AU - Barrón, M.

AU - Bermúdez, P.

AU - Blanquer, R.

AU - Borderías, L.

AU - Bustamante, A.

AU - Calpe, J. L.

AU - Caminero, J. A.

AU - Cañas, F.

AU - Casas, F.

AU - Casas, X.

AU - Cases, E.

AU - Castrodeza, R.

AU - Cebrián, J. J.

AU - Ciruelos, J. E.

AU - Delgado, A. E.

AU - de Souza, M. L.

AU - Díaz, D.

AU - Fernández, B.

AU - Fernández, A.

AU - Gallardo, J.

AU - Gallego, M.

AU - GarcíaClemente, M. M.

AU - García, C.

AU - García, F. J.

AU - Garros, F. J.

AU - Gullón, J. A.

AU - Hidalgo, C.

AU - Iglesias, M.

AU - Jiménez, G.

AU - Jiménez, M. A.

AU - Kindelan, J. M.

AU - Laparra, J.

AU - Lera, R.

AU - Lloret, T.

AU - Marín, M.

AU - Martínez, J. T.

AU - Martínez, E.

AU - Martínez, A.

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Introduction: International and Spanish guidelines recommend a 4-drug regimen in the intensive treatment of tuberculosis (TB). The aim of our study was to determine if these recommendations are followed in Spain, and the factors associated with the use of 3 drugs (standard regimen without ethambutol). Methodology: Observational, multicenter, retrospective analysis of data from patients diagnosed with TB in practically all Spanish Autonomous Communities between 2007 and 2102. Factors associated with the use of 3 drugs were analyzed using logistic regression, and odds ratios (OR) and corresponding 95% confidence intervals (CI) were calculated. Results: A total of 3,189 patients were included, 1,413 (44.3%) of whom received 3 drugs. The percentage of 3-drug users among patients with positive sputum smear was 41.2%; among patients with resistance to at least 1 drug, 36.1%; among HIV-infected patients, 31.4%; and among immigrants, 24.8%. Factors associated with the use of 3 drugs were: female sex (OR = 1.18; CI: 1.00-1.39); native Spanish (OR = 3.09; CI: 2.58-3.70); retired (OR = 1.42; CI: 1.14-1.77); homeless (OR = 3.10; CI: 1.52-6.43); living alone (OR = 1.62; CI: 1.11-2.36); living in a family (OR = 1.97; CI: 1.48-2.65); seen by specialists in the region (OR = 1.37; CI: 1.10;1.70); no HIV infection (OR = 1.63; CI: 1.09-2.48); and negative sputum smear with positive culture (OR = 1.59; CI: 1.25-2.02). Conclusions: A large proportion of TB patients receive intensive treatment with 3 drugs. TB treatment recommendations should be followed, both in routine clinical practice and by the National Plan for Prevention and Control of Tuberculosis in Spain.

AB - Introduction: International and Spanish guidelines recommend a 4-drug regimen in the intensive treatment of tuberculosis (TB). The aim of our study was to determine if these recommendations are followed in Spain, and the factors associated with the use of 3 drugs (standard regimen without ethambutol). Methodology: Observational, multicenter, retrospective analysis of data from patients diagnosed with TB in practically all Spanish Autonomous Communities between 2007 and 2102. Factors associated with the use of 3 drugs were analyzed using logistic regression, and odds ratios (OR) and corresponding 95% confidence intervals (CI) were calculated. Results: A total of 3,189 patients were included, 1,413 (44.3%) of whom received 3 drugs. The percentage of 3-drug users among patients with positive sputum smear was 41.2%; among patients with resistance to at least 1 drug, 36.1%; among HIV-infected patients, 31.4%; and among immigrants, 24.8%. Factors associated with the use of 3 drugs were: female sex (OR = 1.18; CI: 1.00-1.39); native Spanish (OR = 3.09; CI: 2.58-3.70); retired (OR = 1.42; CI: 1.14-1.77); homeless (OR = 3.10; CI: 1.52-6.43); living alone (OR = 1.62; CI: 1.11-2.36); living in a family (OR = 1.97; CI: 1.48-2.65); seen by specialists in the region (OR = 1.37; CI: 1.10;1.70); no HIV infection (OR = 1.63; CI: 1.09-2.48); and negative sputum smear with positive culture (OR = 1.59; CI: 1.25-2.02). Conclusions: A large proportion of TB patients receive intensive treatment with 3 drugs. TB treatment recommendations should be followed, both in routine clinical practice and by the National Plan for Prevention and Control of Tuberculosis in Spain.

KW - Adherence

KW - Guidelines

KW - Treatment

KW - Tuberculosis

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U2 - 10.1016/j.arbr.2016.03.009

DO - 10.1016/j.arbr.2016.03.009

M3 - Article

AN - SCOPUS:85027239473

SN - 0300-2896

VL - 52

SP - 262

EP - 268

JO - Archivos de Bronconeumologia

JF - Archivos de Bronconeumologia

IS - 5

ER -

Cumplimiento en España de la norma de prescribir cuatro fármacos en la fase intensiva del tratamiento estándar de la tuberculosis

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Keywords

ASJC Scopus subject areas

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