Cul catalyzed N-arylation of amide as a key step for the preparation of 3-aryl β-carbolin-1-ones

Shaozhong Wang; Jianwei Sun; Gang Yu; Xiaoyi Hu; Jun O. Liu; Yuefei Hu

doi:10.1039/b406046f

Cul catalyzed N-arylation of amide as a key step for the preparation of 3-aryl β-carbolin-1-ones

Shaozhong Wang, Jianwei Sun, Gang Yu, Xiaoyi Hu, Jun O. Liu, Yuefei Hu

School of Medicine

Research output: Contribution to journal › Review article › peer-review

24 Scopus citations

Abstract

An expedient synthetic route for 3-aryl β-carbolin-1-ones was developed starting from ethyl acetamidocyanoacetate and chalcone derivatives. The five- and six-membered nitrogen-containing rings in the β-carbolin-1- ones were elaborated efficiently by an intramolecular ketone-nitrile annulation and an intramolecular N-arylation of amide respectively.

Original language	English (US)
Pages (from-to)	1573-1574
Number of pages	2
Journal	Organic and Biomolecular Chemistry
Volume	2
Issue number	11
DOIs	https://doi.org/10.1039/b406046f
State	Published - Jun 7 2004

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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abstract = "An expedient synthetic route for 3-aryl β-carbolin-1-ones was developed starting from ethyl acetamidocyanoacetate and chalcone derivatives. The five- and six-membered nitrogen-containing rings in the β-carbolin-1- ones were elaborated efficiently by an intramolecular ketone-nitrile annulation and an intramolecular N-arylation of amide respectively.",

author = "Shaozhong Wang and Jianwei Sun and Gang Yu and Xiaoyi Hu and Liu, {Jun O.} and Yuefei Hu",

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T1 - Cul catalyzed N-arylation of amide as a key step for the preparation of 3-aryl β-carbolin-1-ones

AU - Wang, Shaozhong

AU - Sun, Jianwei

AU - Yu, Gang

AU - Hu, Xiaoyi

AU - Liu, Jun O.

AU - Hu, Yuefei

PY - 2004/6/7

Y1 - 2004/6/7

N2 - An expedient synthetic route for 3-aryl β-carbolin-1-ones was developed starting from ethyl acetamidocyanoacetate and chalcone derivatives. The five- and six-membered nitrogen-containing rings in the β-carbolin-1- ones were elaborated efficiently by an intramolecular ketone-nitrile annulation and an intramolecular N-arylation of amide respectively.

AB - An expedient synthetic route for 3-aryl β-carbolin-1-ones was developed starting from ethyl acetamidocyanoacetate and chalcone derivatives. The five- and six-membered nitrogen-containing rings in the β-carbolin-1- ones were elaborated efficiently by an intramolecular ketone-nitrile annulation and an intramolecular N-arylation of amide respectively.

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JF - Organic and Biomolecular Chemistry

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ER -

Cul catalyzed N-arylation of amide as a key step for the preparation of 3-aryl β-carbolin-1-ones

Abstract

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