CTCAE v3.0: Development of a comprehensive grading system for the adverse effects of cancer treatment

Andy Trotti, A. Dimitrios Colevas, Ann Setser, Valerie Rusch, David Jaques, Volker Budach, Corey Langer, Barbara Murphy, Richard Cumberlin, C. Norman Coleman, Philip Rubin

Research output: Contribution to journalArticlepeer-review

1965 Scopus citations


Multiple systems have been developed for grading the adverse effects (AEs) of cancer treatment. The National Cancer Institute Common Toxicity Criteria (CTC) system has substantially evolved since its inception in 1983. The most recent version, CTCAE v3.0 (Common Terminology Criteria for Adverse Events version 3.0) represents the first comprehensive, multimodality grading system for reporting the acute and late effects of cancer treatment. The new CTC requires changes in the application of AE criteria including new guidelines regarding late effects, surgical and pediatric effects, multimodality issues, and for reporting the duration of an effect. It builds on the strengths of previous systems, represents a considerable effort among hundreds of participants, and signifies an international collaboration and consensus of the oncology research community. This article updates recent progress in the evolution of adverse effects grading systems and reviews the development of CTCAE v3.0.

Original languageEnglish (US)
Pages (from-to)176-181
Number of pages6
JournalSeminars in Radiation Oncology
Issue number3
StatePublished - Jul 2003
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research


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