CT Perfusion: Ready for prime time

Marietta S. Ambrose; Carolina Valdiviezo; Vishal Mehra; Albert C. Lardo; Joao A.C. Lima; Richard T. George

doi:10.1007/s11886-010-0152-3

CT Perfusion: Ready for prime time

Marietta S. Ambrose, Carolina Valdiviezo, Vishal Mehra, Albert C. Lardo, Joao A.C. Lima, Richard T. George

School of Medicine

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Advancements in computed tomography (CT) technology have revolutionized clinical practice, particularly regarding the noninvasive assessment of coronary artery disease (CAD). The versatility of cardiac CT has rendered multiple applications including assessment of cardiac structure and function, myocardial viability, and coronary anatomy. The merits of cardiac computed tomography angiography (CTA) have been proven for the detection, and particularly the exclusion, of CAD. However, CTA becomes limited in the presence of significant CAD. Its inability to consistently identify lesion-associated ischemia may necessitate additional radionuclide myocardial perfusion imaging. Myocardial computed tomography perfusion imaging (CTP) has emerged as a useful and convenient method to immediately assess myocardial ischemia. In this review, we discuss the current state of CTP including available technology, its performance to date from current literature, and future challenges to this field.

Original language	English (US)
Pages (from-to)	57-66
Number of pages	10
Journal	Current Cardiology Reports
Volume	13
Issue number	1
DOIs	https://doi.org/10.1007/s11886-010-0152-3
State	Published - Feb 2011

Keywords

CAD
CT perfusion imaging
CTA
Cardiac stress test
Coronary
Dual-source CT
Dynamic CT
Helical CT
MDCT
Myocardial blood flow
Myocardial perfusion
Noninvasive testing

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1007/s11886-010-0152-3

Cite this

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title = "CT Perfusion: Ready for prime time",

abstract = "Advancements in computed tomography (CT) technology have revolutionized clinical practice, particularly regarding the noninvasive assessment of coronary artery disease (CAD). The versatility of cardiac CT has rendered multiple applications including assessment of cardiac structure and function, myocardial viability, and coronary anatomy. The merits of cardiac computed tomography angiography (CTA) have been proven for the detection, and particularly the exclusion, of CAD. However, CTA becomes limited in the presence of significant CAD. Its inability to consistently identify lesion-associated ischemia may necessitate additional radionuclide myocardial perfusion imaging. Myocardial computed tomography perfusion imaging (CTP) has emerged as a useful and convenient method to immediately assess myocardial ischemia. In this review, we discuss the current state of CTP including available technology, its performance to date from current literature, and future challenges to this field.",

keywords = "CAD, CT perfusion imaging, CTA, Cardiac stress test, Coronary, Dual-source CT, Dynamic CT, Helical CT, MDCT, Myocardial blood flow, Myocardial perfusion, Noninvasive testing",

author = "Ambrose, {Marietta S.} and Carolina Valdiviezo and Vishal Mehra and Lardo, {Albert C.} and Lima, {Joao A.C.} and George, {Richard T.}",

note = "Funding Information: Conflicts of interest M.S. Ambrose: none; C. Valdiviezo: none: V. Mehra: none: A.C. Lardo: receives research funding from Toshiba Medical Systems; J.A.C. Lima: receives research funding from Toshiba Medical Systems, and receives research funding and serves on the advisory board of Astellas Pharma US, Inc. The terms of these arrangements are managed by Johns Hopkins University in accordance with its conflict of interest policies; R.T. George: receives research funding from Toshiba Medical Systems, and receives research funding and serves on the advisory board of Astellas Pharma US, Inc. The terms of these arrangements are managed by Johns Hopkins University in accordance with its conflict of interest policies. He also has a patent pending for CT Myocardial Perfusion Imaging.",

year = "2011",

month = feb,

doi = "10.1007/s11886-010-0152-3",

language = "English (US)",

volume = "13",

pages = "57--66",

journal = "Current Cardiology Reports",

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AU - Ambrose, Marietta S.

AU - Valdiviezo, Carolina

AU - Mehra, Vishal

AU - Lardo, Albert C.

AU - Lima, Joao A.C.

AU - George, Richard T.

N1 - Funding Information: Conflicts of interest M.S. Ambrose: none; C. Valdiviezo: none: V. Mehra: none: A.C. Lardo: receives research funding from Toshiba Medical Systems; J.A.C. Lima: receives research funding from Toshiba Medical Systems, and receives research funding and serves on the advisory board of Astellas Pharma US, Inc. The terms of these arrangements are managed by Johns Hopkins University in accordance with its conflict of interest policies; R.T. George: receives research funding from Toshiba Medical Systems, and receives research funding and serves on the advisory board of Astellas Pharma US, Inc. The terms of these arrangements are managed by Johns Hopkins University in accordance with its conflict of interest policies. He also has a patent pending for CT Myocardial Perfusion Imaging.

PY - 2011/2

Y1 - 2011/2

N2 - Advancements in computed tomography (CT) technology have revolutionized clinical practice, particularly regarding the noninvasive assessment of coronary artery disease (CAD). The versatility of cardiac CT has rendered multiple applications including assessment of cardiac structure and function, myocardial viability, and coronary anatomy. The merits of cardiac computed tomography angiography (CTA) have been proven for the detection, and particularly the exclusion, of CAD. However, CTA becomes limited in the presence of significant CAD. Its inability to consistently identify lesion-associated ischemia may necessitate additional radionuclide myocardial perfusion imaging. Myocardial computed tomography perfusion imaging (CTP) has emerged as a useful and convenient method to immediately assess myocardial ischemia. In this review, we discuss the current state of CTP including available technology, its performance to date from current literature, and future challenges to this field.

AB - Advancements in computed tomography (CT) technology have revolutionized clinical practice, particularly regarding the noninvasive assessment of coronary artery disease (CAD). The versatility of cardiac CT has rendered multiple applications including assessment of cardiac structure and function, myocardial viability, and coronary anatomy. The merits of cardiac computed tomography angiography (CTA) have been proven for the detection, and particularly the exclusion, of CAD. However, CTA becomes limited in the presence of significant CAD. Its inability to consistently identify lesion-associated ischemia may necessitate additional radionuclide myocardial perfusion imaging. Myocardial computed tomography perfusion imaging (CTP) has emerged as a useful and convenient method to immediately assess myocardial ischemia. In this review, we discuss the current state of CTP including available technology, its performance to date from current literature, and future challenges to this field.

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KW - Myocardial perfusion

KW - Noninvasive testing

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CT Perfusion: Ready for prime time

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Keywords

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