TY - JOUR
T1 - CT measurement of suprasellar cistern predicts rate of cognitive decline in Alzheimer's disease
AU - Aylward, Elizabeth H.
AU - Rasmusson, D. Xeno
AU - Brandt, Jason
AU - Raimundo, Lisa
AU - Folstein, Marshal
AU - Pearlson, Godfrey D.
N1 - Funding Information:
This project was supported in part by the following grants: NIH Division of Research Resources/Johns Hopkins Outpatient Clinical Research Center (RR07222), Alzheimer's Disease Research Center (AG08327), Training in the Dementias of Aging (AG00149), an Investigator Initiated Research Grant from the Alzheimer's Association, and the Johns Hopkins Interdisciplinary Committee on NMR Research. Portions of this paper were presented at the American Psychiatric Association 145th Annual Meeting, May 2-7, 1992, Washington, DC.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 1996
Y1 - 1996
N2 - Previous studies reveal significant relationships between some quantitative computed tomography (CT) measures and level of cognitive functioning in patients with Alzheimer's disease (AD). This study was designed to determine whether measurements from CT scans of AD patients could predict future rates of decline in cognitive function. Subjects were 8 men and 19 women diagnosed with probable AD. CT measures included bifrontal ratio, bicaudate ratio, and areas of laleral ventricles, third ventricle, and suprasellar cistern (SSC). Measures of cognitive and adaptive functioning were obtained at the time of the scan and on followup. Of the CT measures, the SSCR (SSC corrected for intracranial area) was the most highly correlated with Mini-Mental State Exam (MMSE) score and other cognitive measures at the time of the scan. Follow-up data were obtained for those 20 individuals who were mildly to moderately demented at the time of the scan (MMSE ≥ 10). Rate of change was calculated for each neuropsychological measure. The SSCR correlated significantly with rate of change for MMSE and other measures of cognitive and adaptive functioning. This study demonstrates that CT measurement of the SSC can predict the subsequent rate of neurocognitive decline in AD patients. (JINS, 1996, 2, 89-95.).
AB - Previous studies reveal significant relationships between some quantitative computed tomography (CT) measures and level of cognitive functioning in patients with Alzheimer's disease (AD). This study was designed to determine whether measurements from CT scans of AD patients could predict future rates of decline in cognitive function. Subjects were 8 men and 19 women diagnosed with probable AD. CT measures included bifrontal ratio, bicaudate ratio, and areas of laleral ventricles, third ventricle, and suprasellar cistern (SSC). Measures of cognitive and adaptive functioning were obtained at the time of the scan and on followup. Of the CT measures, the SSCR (SSC corrected for intracranial area) was the most highly correlated with Mini-Mental State Exam (MMSE) score and other cognitive measures at the time of the scan. Follow-up data were obtained for those 20 individuals who were mildly to moderately demented at the time of the scan (MMSE ≥ 10). Rate of change was calculated for each neuropsychological measure. The SSCR correlated significantly with rate of change for MMSE and other measures of cognitive and adaptive functioning. This study demonstrates that CT measurement of the SSC can predict the subsequent rate of neurocognitive decline in AD patients. (JINS, 1996, 2, 89-95.).
KW - Alzheimer's disease
KW - CT
KW - Cognitive decline
KW - Neuroimaging
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U2 - 10.1017/s135561770000093x
DO - 10.1017/s135561770000093x
M3 - Article
C2 - 9375193
AN - SCOPUS:0030089598
SN - 1355-6177
VL - 2
SP - 89
EP - 95
JO - Journal of the International Neuropsychological Society
JF - Journal of the International Neuropsychological Society
IS - 2
ER -