CT imaging of congenital lung lesions: effect of iterative reconstruction on diagnostic performance and radiation dose

Jay E. Haggerty, Ethan A. Smith, Shaun M. Kunisaki, Jonathan R. Dillman

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Background: Different iterative reconstruction techniques are available for use in pediatric computed tomography (CT), but these techniques have not been systematically evaluated in infants. Objective: To determine the effect of iterative reconstruction on diagnostic performance, image quality and radiation dose in infants undergoing CT evaluation for congenital lung lesions. Materials and methods: A retrospective review of contrast-enhanced chest CT in infants (<1 year) with congenital lung lesions was performed. CT examinations were reviewed to document the type of lung lesion, vascular anatomy, image noise measurements and image reconstruction method. CTDIvol was used to calculate size-specific dose estimates (SSDE). CT findings were correlated with intraoperative and histopathological findings. Analysis of variance and the Student’s t-test were used to compare image noise measurements and radiation dose estimates between groups. Results: Fifteen CT examinations used filtered back projection (FBP; mean age: 84 days), 15 used adaptive statistical iterative reconstruction (ASiR; mean age: 93 days), and 11 used model-based iterative reconstruction (MBIR; mean age: 98 days). Compared to operative findings, 13/15 (87%), 14/15 (93%) and 11/11 (100%) lesions were correctly characterized using FBP, ASiR and MBIR, respectively. Arterial anatomy was correctly identified in 12/15 (80%) using FBP, 13/15 (87%) using ASiR and 11/11 (100%) using MBIR. Image noise was less for MBIR vs. ASiR (P < 0.0001). Mean SSDE was different among groups (P = 0.003; FBP = 7.35 mGy, ASiR = 1.89 mGy, MBIR = 1.49 mGy). Conclusion: Congenital lung lesions can be adequately characterized in infants using iterative CT reconstruction techniques while maintaining image quality and lowering radiation dose.

Original languageEnglish (US)
Pages (from-to)989-997
Number of pages9
JournalPediatric radiology
Issue number7
StatePublished - Jul 1 2015
Externally publishedYes


  • Computed tomography
  • Congenital pulmonary airway malformation
  • Infant
  • Iterative reconstruction
  • Lung
  • Radiation dose
  • Sequestration

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Radiology Nuclear Medicine and imaging


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