John R. Perfect, Arturo Casadevall

Research output: Contribution to journalReview articlepeer-review

338 Scopus citations


Cryptococcus neoformans has risen to a worldwide highly recognizable major opportunistic pathogen with deadly consequences. It has become a model fungus to study a variety of paradigms in the host-fungus relationships. Genomic studies are advancing knowledge on its evolution and dissecting its virulence composite. Studies designed to understand host immunology to this fungus are leading to development of active and passive prevention and therapeutic strategies. This article collates and analyzes both new and old knowledge about the pathogen to help frame the meaning of human cryptococcosis as it starts to evolve in the new millennium.

Original languageEnglish (US)
Pages (from-to)837-874
Number of pages38
JournalInfectious disease clinics of North America
Issue number4
StatePublished - Dec 2002
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases


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