Cryosurgery for unresectable primary hepatocellular carcinoma: A case report and review of literature

Joseph V. Pergolizzi, Martin Auster, Gail L. Conaway, Armando Sardi

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Primary liver cancers are a significant cause of both morbidity and mortality. Although surgical resection remains the treatment of choice for these tumors, only 10 to 20 per cent of the primary liver tumors are found to be resectable. Presently, the options for these patients include liver transplantation, cryosurgery, or nonsurgical therapy, such as transarterial chemoembolization. Techniques such as alcohol injection, interstitial radiotherapy, laser hypothermia, and radiofrequency electrodissection have all been attempted with limited success. We present a case of a 68-year-old woman with a 10-year history of liver cirrhosis secondary to chronic active hepatitis C. A lateral segmentectomy was recommended but could not be done due to severe underlying cirrhosis. Cryosurgery aided by intraoperative ultrasonography was performed successfully. The patient developed recurrent disease at 58 months and died with disease at 62 months. Advances in instrumentation and intraoperative ultrasonography are making cryosurgery a viable surgical therapeutic alternative in the management of patients with unresectable hepatocellular carcinoma. The procedure can be performed safely with low morbidity.

Original languageEnglish (US)
Pages (from-to)402-405
Number of pages4
JournalAmerican Surgeon
Issue number5
StatePublished - May 1 1999
Externally publishedYes

ASJC Scopus subject areas

  • Surgery


Dive into the research topics of 'Cryosurgery for unresectable primary hepatocellular carcinoma: A case report and review of literature'. Together they form a unique fingerprint.

Cite this