Cross-modal synaptic plasticity in adult primary sensory cortices

Hey Kyoung Lee, Jessica L. Whitt

Research output: Contribution to journalReview articlepeer-review

42 Scopus citations


Sensory loss leads to widespread adaptation of brain circuits to allow an organism to navigate its environment with its remaining senses, which is broadly referred to as cross-modal plasticity. Such adaptation can be observed even in the primary sensory cortices, and falls into two distinct categories: recruitment of the deprived sensory cortex for processing the remaining senses, which we term 'cross-modal recruitment', and experience-dependent refinement of the spared sensory cortices referred to as 'compensatory plasticity.' Here we will review recent studies demonstrating that cortical adaptation to sensory loss involves LTP/LTD and homeostatic synaptic plasticity. Cross-modal synaptic plasticity is observed in adults, hence cross-modal sensory deprivation may be an effective way to promote plasticity in adult primary sensory cortices.

Original languageEnglish (US)
Pages (from-to)119-126
Number of pages8
JournalCurrent Opinion in Neurobiology
StatePublished - Dec 1 2015

ASJC Scopus subject areas

  • Neuroscience(all)


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