Critical role of Syk-dependent STAT1 activation in innate antiviral immunity

Shasha Liu; Yuan Liao; Biao Chen; Yuhai Chen; Ziding Yu; Haitao Wei; Lianfeng Zhang; Shile Huang; Paul B. Rothman; George Fu Gao; Ji Long Chen

doi:10.1016/j.celrep.2020.108627

Critical role of Syk-dependent STAT1 activation in innate antiviral immunity

Shasha Liu
, Yuan Liao
, Biao Chen
, Yuhai Chen
, Ziding Yu
, Haitao Wei
, Lianfeng Zhang
, Shile Huang
, Paul B. Rothman
, George Fu Gao
, Ji Long Chen

School of Medicine

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Liu et al. describe a role of Syk-dependent STAT1 activation in innate antiviral immunity. Initial activation of STAT1 during IAV infection is regulated by RIG-I/MAVS/Syk signaling. Additionally, STAT1 Tyr-701 is a critical residue for the antiviral response. Conditional Syk knockout and STAT1 Y701F knockin mouse models corroborate these findings.

Original language	English (US)
Article number	108627
Journal	Cell Reports
Volume	34
Issue number	3
DOIs	https://doi.org/10.1016/j.celrep.2020.108627
State	Published - Jan 19 2021

Keywords

MAVS
RIG-I
STAT1
Syk
cytokine
influenza virus
innate immunity

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1016/j.celrep.2020.108627

Cite this

@article{cf1e1c655f3b4cb98134b32ecb351ffb,

title = "Critical role of Syk-dependent STAT1 activation in innate antiviral immunity",

abstract = "Liu et al. describe a role of Syk-dependent STAT1 activation in innate antiviral immunity. Initial activation of STAT1 during IAV infection is regulated by RIG-I/MAVS/Syk signaling. Additionally, STAT1 Tyr-701 is a critical residue for the antiviral response. Conditional Syk knockout and STAT1 Y701F knockin mouse models corroborate these findings.",

keywords = "MAVS, RIG-I, STAT1, Syk, cytokine, influenza virus, innate immunity",

author = "Shasha Liu and Yuan Liao and Biao Chen and Yuhai Chen and Ziding Yu and Haitao Wei and Lianfeng Zhang and Shile Huang and Rothman, \{Paul B.\} and Gao, \{George Fu\} and Chen, \{Ji Long\}",

note = "Funding Information: This work was supported by the National Natural Science Foundation of China ( U1805231 and 32030110 ), National Key Research and Development Program of China ( 2016YFD0500206 ), National Key Research and Development Program of China ( 2016YFC1200304 ), and National Natural Science Foundation of China ( 31600147 and 81502397 ). Funding for open access charge: National Natural Science Foundation of China ( U1805231 ). Publisher Copyright: {\textcopyright} 2020 The Author(s)",

year = "2021",

month = jan,

day = "19",

doi = "10.1016/j.celrep.2020.108627",

language = "English (US)",

volume = "34",

journal = "Cell Reports",

issn = "2211-1247",

publisher = "Elsevier BV",

number = "3",

}

TY - JOUR

T1 - Critical role of Syk-dependent STAT1 activation in innate antiviral immunity

AU - Liu, Shasha

AU - Liao, Yuan

AU - Chen, Biao

AU - Chen, Yuhai

AU - Yu, Ziding

AU - Wei, Haitao

AU - Zhang, Lianfeng

AU - Huang, Shile

AU - Rothman, Paul B.

AU - Gao, George Fu

AU - Chen, Ji Long

N1 - Funding Information: This work was supported by the National Natural Science Foundation of China ( U1805231 and 32030110 ), National Key Research and Development Program of China ( 2016YFD0500206 ), National Key Research and Development Program of China ( 2016YFC1200304 ), and National Natural Science Foundation of China ( 31600147 and 81502397 ). Funding for open access charge: National Natural Science Foundation of China ( U1805231 ). Publisher Copyright: © 2020 The Author(s)

PY - 2021/1/19

Y1 - 2021/1/19

N2 - Liu et al. describe a role of Syk-dependent STAT1 activation in innate antiviral immunity. Initial activation of STAT1 during IAV infection is regulated by RIG-I/MAVS/Syk signaling. Additionally, STAT1 Tyr-701 is a critical residue for the antiviral response. Conditional Syk knockout and STAT1 Y701F knockin mouse models corroborate these findings.

AB - Liu et al. describe a role of Syk-dependent STAT1 activation in innate antiviral immunity. Initial activation of STAT1 during IAV infection is regulated by RIG-I/MAVS/Syk signaling. Additionally, STAT1 Tyr-701 is a critical residue for the antiviral response. Conditional Syk knockout and STAT1 Y701F knockin mouse models corroborate these findings.

KW - MAVS

KW - RIG-I

KW - STAT1

KW - Syk

KW - cytokine

KW - influenza virus

KW - innate immunity

UR - https://www.scopus.com/pages/publications/85099562238

UR - https://www.scopus.com/pages/publications/85099562238#tab=citedBy

U2 - 10.1016/j.celrep.2020.108627

DO - 10.1016/j.celrep.2020.108627

M3 - Article

C2 - 33472080

AN - SCOPUS:85099562238

SN - 2211-1247

VL - 34

JO - Cell Reports

JF - Cell Reports

IS - 3

M1 - 108627

ER -

Critical role of Syk-dependent STAT1 activation in innate antiviral immunity

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this