Critical drug interactions: A guide to important examples

D. R. Abernethy, N. S. Andrawis

Research output: Contribution to journalReview articlepeer-review


It is critical that the physician have access to information delineating present pharmacotherapeutic knowledge when evaluating a patient for possible drug-drug interactions. Pharmacokinetic, or metabolic, drug interactions include those that alter the disposition and effects of drugs having a narrow therapeutic index and the hepatic oxidation or renal clearance of low- therapeutic-index drugs. Genetically based interactions may involve drugs that are metabolized by the hepatic cytochrome P-450 enzyme, now called CYPIID6. Pharmacodynamic drug interactions are much less studied and resist classification, although the authors enumerate some important mechanisms.

Original languageEnglish (US)
Pages (from-to)15-16+19+23+27
JournalDrug Therapy
Issue number10
StatePublished - Jan 1 1993

ASJC Scopus subject areas

  • Pharmaceutical Science


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