Critical care sedation for neuroscience patients

Marek A. Mirski, Mitzi K. Hemstreet

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


In 2000, the Joint Commission on Accreditation of Healthcare Organizations (JCAHO) introduced the mandate for the implementation of standards for both pain assessment and need for therapy in hospitalized patients. The need for the appropriate titration of sedation and analgesia is particularly poignant in an intensive care unit (ICU) setting where iatrogenic discomfort often complicates patient management. Neurologically ill patients in ICUs present particularly complex sedation issues, owing to the need to monitor these patients with serial neurological exams. Hence, maximal comfort without diminishing neurological responsiveness is desirable. Here, we review the frequently applied methods of evaluating levels of pain and agitation in critically ill patients as well as discuss the appropriate classes of pharmaceutical agents common to this population, with particular emphasis on the potential neurophysiological impact of such therapy.

Original languageEnglish (US)
Pages (from-to)16-34
Number of pages19
JournalJournal of the Neurological Sciences
Issue number1-2
StatePublished - Oct 15 2007


  • ICU
  • Pharmacokinetics
  • Sedation

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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