CRIM1 is necessary for coronary vascular endothelial cell development and homeostasis

Swati Iyer, Yash Chhabra, Tracey J. Harvey, Richard Wang, Han Sheng Chiu, A. G. Smith, Walter G. Thomas, David J. Pennisi, Michael Piper

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Endothelial cells form a critical component of the coronary vasculature, yet the factors regulating their development remain poorly defined. Here we reveal a novel role for the transmembrane protein CRIM1 in mediating cardiac endothelial cell development. In the absence of Crim1 in vivo, the coronary vasculature is malformed, the number of endothelial cells reduced, and the canonical BMP pathway dysregulated. Moreover, we reveal that CRIM1 can bind IGFs, and regulate IGF signalling within endothelial cells. Finally, loss of CRIM1 from human cardiac endothelial cells results in misregulation of endothelial genes, predicted by pathway analysis to be involved in an increased inflammatory response and cytolysis, reminiscent of endothelial cell dysfunction in cardiovascular disease pathogenesis. Collectively, these findings implicate CRIM1 in endothelial cell development and homeostasis in the coronary vasculature.

Original languageEnglish (US)
Pages (from-to)53-61
Number of pages9
JournalJournal of Molecular Histology
Issue number1
StatePublished - Feb 1 2017
Externally publishedYes


  • Crim 1
  • Endothelial cells
  • Heart

ASJC Scopus subject areas

  • Histology
  • Physiology
  • Cell Biology


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