TY - JOUR
T1 - Cranial volume, mild cognitive deficits, and functional limitations associated with diabetes in a community sample
AU - Christman, Andrea L.
AU - Vannorsdall, Tracy D.
AU - Pearlson, Godfrey D.
AU - Hill-Briggs, Felicia
AU - Schretlen, David J.
N1 - Funding Information:
This research was funded by a grant from NIMH (R01MH060504). FHB is supported by the NIDDK Diabetes Research and Training Center (P60 DK079637).
PY - 2010/2
Y1 - 2010/2
N2 - Diabetes is associated with dementia in older adults, but it remains unclear whether nondemented adults with type 2 diabetes show subtle abnormalities across cognition, neuroanatomy, and everyday functioning. Using the Aging, Brain Imaging, and Cognition study sample of 301 community-dwelling, middle-aged and older adults, we conducted a secondary analysis on 28 participants with and 150 participants without diabetes. We analyzed brain magnetic resonance imaging data, cognitive test performance, and informant ratings of personal and instrumental activities of daily living (PADL/IADL). Relative to controls, participants with diabetes had lower brain-to-intracranial volume ratios (69.3 ± 4.5% vs. 71.7 ± 4.6%; p <. 02), and performed more poorly on measures of working memory, processing speed, fluency, and crystallized intelligence (all p <.05). Decrements in working memory and processing speed were associated with IADL limitations (p <. 01). Nondemented adults with diabetes exhibit neuroanatomic and cognitive abnormalities. Their cognitive deficits correlate with everyday functional limitations.
AB - Diabetes is associated with dementia in older adults, but it remains unclear whether nondemented adults with type 2 diabetes show subtle abnormalities across cognition, neuroanatomy, and everyday functioning. Using the Aging, Brain Imaging, and Cognition study sample of 301 community-dwelling, middle-aged and older adults, we conducted a secondary analysis on 28 participants with and 150 participants without diabetes. We analyzed brain magnetic resonance imaging data, cognitive test performance, and informant ratings of personal and instrumental activities of daily living (PADL/IADL). Relative to controls, participants with diabetes had lower brain-to-intracranial volume ratios (69.3 ± 4.5% vs. 71.7 ± 4.6%; p <. 02), and performed more poorly on measures of working memory, processing speed, fluency, and crystallized intelligence (all p <.05). Decrements in working memory and processing speed were associated with IADL limitations (p <. 01). Nondemented adults with diabetes exhibit neuroanatomic and cognitive abnormalities. Their cognitive deficits correlate with everyday functional limitations.
KW - Behavior
KW - Cognition
KW - Diabetes
KW - Endocrine disorders
KW - Function
KW - MRI
KW - Neuropsychological testing
UR - http://www.scopus.com/inward/record.url?scp=76149090198&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=76149090198&partnerID=8YFLogxK
U2 - 10.1093/arclin/acp091
DO - 10.1093/arclin/acp091
M3 - Article
C2 - 19942595
AN - SCOPUS:76149090198
SN - 0887-6177
VL - 25
SP - 49
EP - 59
JO - Archives of Clinical Neuropsychology
JF - Archives of Clinical Neuropsychology
IS - 1
ER -