COX1 and COX2 polymorphisms and gastric cancer risk in a polish population

Lifang Hou; Paolo Grillo; Zhong Zheng Zhu; Jola Lissowska; Meredith Yeager; Witold Zatonski; Guanshan Zhu; Andrea Baccarelli; Stephen J. Chanock; Joseph F. Fraumeni; Wong Ho Chow

COX1 and COX2 polymorphisms and gastric cancer risk in a polish population

Lifang Hou, Paolo Grillo, Zhong Zheng Zhu, Jola Lissowska, Meredith Yeager, Witold Zatonski, Guanshan Zhu, Andrea Baccarelli, Stephen J. Chanock, Joseph F. Fraumeni, Wong Ho Chow

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Background: Although a number of studies on the polymorphisms in COX1 and COX2 genes in association with risks for a number of cancers have been conducted, their relation to gastric cancer has not been well studied. Patients and Methods: Genotypes of several variants in both COX1 (Ex7+31 C>A and Ex10-4 G>A) and COX2 (-765 G>C, Ex10+837 T>C, Ex10-90 C>T, IVS5-275 T>G, and IVS7+111 T>C) were identified by TaqMan™ assays in 305 gastric cancer cases and 427 age- and gender-matched controls in a high-risk Polish population. Odds ratios for gastric cancer and 95% confidence intervals from unconditional logistic regression models were used to evaluate relative risks. Results: We found no statistically significant evidence that the polymorphisms tested in COX1 and COX2 are associated with gastric cancer risk. Conclusion: These results suggest that the polymorphisms examined in COX1 and COX2 do not affect the risk of gastric cancer.

Original language	English (US)
Pages (from-to)	4243-4247
Number of pages	5
Journal	Anticancer research
Volume	27
Issue number	6 C
State	Published - Nov 2007
Externally published	Yes

Keywords

COX1
COX2
Gastric cancer
Polymorphisms

ASJC Scopus subject areas

Oncology
Cancer Research

Cite this

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title = "COX1 and COX2 polymorphisms and gastric cancer risk in a polish population",

abstract = "Background: Although a number of studies on the polymorphisms in COX1 and COX2 genes in association with risks for a number of cancers have been conducted, their relation to gastric cancer has not been well studied. Patients and Methods: Genotypes of several variants in both COX1 (Ex7+31 C>A and Ex10-4 G>A) and COX2 (-765 G>C, Ex10+837 T>C, Ex10-90 C>T, IVS5-275 T>G, and IVS7+111 T>C) were identified by TaqMan{\texttrademark} assays in 305 gastric cancer cases and 427 age- and gender-matched controls in a high-risk Polish population. Odds ratios for gastric cancer and 95% confidence intervals from unconditional logistic regression models were used to evaluate relative risks. Results: We found no statistically significant evidence that the polymorphisms tested in COX1 and COX2 are associated with gastric cancer risk. Conclusion: These results suggest that the polymorphisms examined in COX1 and COX2 do not affect the risk of gastric cancer.",

keywords = "COX1, COX2, Gastric cancer, Polymorphisms",

author = "Lifang Hou and Paolo Grillo and Zhu, {Zhong Zheng} and Jola Lissowska and Meredith Yeager and Witold Zatonski and Guanshan Zhu and Andrea Baccarelli and Chanock, {Stephen J.} and Fraumeni, {Joseph F.} and Chow, {Wong Ho}",

year = "2007",

month = nov,

language = "English (US)",

volume = "27",

pages = "4243--4247",

journal = "Anticancer research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

number = "6 C",

}

TY - JOUR

T1 - COX1 and COX2 polymorphisms and gastric cancer risk in a polish population

AU - Hou, Lifang

AU - Grillo, Paolo

AU - Zhu, Zhong Zheng

AU - Lissowska, Jola

AU - Yeager, Meredith

AU - Zatonski, Witold

AU - Zhu, Guanshan

AU - Baccarelli, Andrea

AU - Chanock, Stephen J.

AU - Fraumeni, Joseph F.

AU - Chow, Wong Ho

PY - 2007/11

Y1 - 2007/11

N2 - Background: Although a number of studies on the polymorphisms in COX1 and COX2 genes in association with risks for a number of cancers have been conducted, their relation to gastric cancer has not been well studied. Patients and Methods: Genotypes of several variants in both COX1 (Ex7+31 C>A and Ex10-4 G>A) and COX2 (-765 G>C, Ex10+837 T>C, Ex10-90 C>T, IVS5-275 T>G, and IVS7+111 T>C) were identified by TaqMan™ assays in 305 gastric cancer cases and 427 age- and gender-matched controls in a high-risk Polish population. Odds ratios for gastric cancer and 95% confidence intervals from unconditional logistic regression models were used to evaluate relative risks. Results: We found no statistically significant evidence that the polymorphisms tested in COX1 and COX2 are associated with gastric cancer risk. Conclusion: These results suggest that the polymorphisms examined in COX1 and COX2 do not affect the risk of gastric cancer.

AB - Background: Although a number of studies on the polymorphisms in COX1 and COX2 genes in association with risks for a number of cancers have been conducted, their relation to gastric cancer has not been well studied. Patients and Methods: Genotypes of several variants in both COX1 (Ex7+31 C>A and Ex10-4 G>A) and COX2 (-765 G>C, Ex10+837 T>C, Ex10-90 C>T, IVS5-275 T>G, and IVS7+111 T>C) were identified by TaqMan™ assays in 305 gastric cancer cases and 427 age- and gender-matched controls in a high-risk Polish population. Odds ratios for gastric cancer and 95% confidence intervals from unconditional logistic regression models were used to evaluate relative risks. Results: We found no statistically significant evidence that the polymorphisms tested in COX1 and COX2 are associated with gastric cancer risk. Conclusion: These results suggest that the polymorphisms examined in COX1 and COX2 do not affect the risk of gastric cancer.

KW - COX1

KW - COX2

KW - Gastric cancer

KW - Polymorphisms

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M3 - Article

C2 - 18214026

AN - SCOPUS:37549010968

SN - 0250-7005

VL - 27

SP - 4243

EP - 4247

JO - Anticancer research

JF - Anticancer research

IS - 6 C

ER -

COX1 and COX2 polymorphisms and gastric cancer risk in a polish population

Abstract

Keywords

ASJC Scopus subject areas

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