Abstract
Coronavirus Disease 2019 (COVID-19) has been the most severe public health challenge in this century. Two years after its emergence, the rapid development and deployment of effective COVID-19 vaccines have successfully controlled this pandemic and greatly reduced the risk of severe illness and death associated with COVID-19. However, due to its ability to rapidly evolve, the SARS-CoV-2 virus may never be eradicated, and there are many important new topics to work on if we need to live with this virus for a long time. To this end, we hope to provide essential knowledge for researchers who work on the improvement of future COVID-19 vaccines. In this review, we provided an up-to-date summary for current COVID-19 vaccines, discussed the biological basis and clinical impact of SARS-CoV-2 variants and subvariants, and analyzed the effectiveness of various vaccine booster regimens against different SARS-CoV-2 strains. Additionally, we reviewed potential mechanisms of vaccine-induced severe adverse events, summarized current studies regarding immune correlates of protection, and finally, discussed the development of next-generation vaccines.
Original language | English (US) |
---|---|
Article number | 82 |
Journal | Journal of biomedical science |
Volume | 29 |
Issue number | 1 |
DOIs | |
State | Published - Dec 2022 |
Keywords
- COVID-19
- Immunity
- SARS-CoV-2
- Vaccine
- Variant
ASJC Scopus subject areas
- Biochemistry, medical
- Pharmacology (medical)
- Molecular Biology
- Clinical Biochemistry
- Endocrinology, Diabetes and Metabolism
- Cell Biology