TY - JOUR
T1 - COVID-19 through Adverse Outcome Pathways
T2 - Building Networks to Better Understand the Disease - 3rd CIAO AOP Design Workshop
AU - Clerbaux, Laure Alix
AU - Amigó, Núria
AU - Amorim, Maria João
AU - Bal-Price, Anna
AU - Leite, Sofia Batista
AU - Beronius, Anna
AU - Bezemer, Gillina F.G.
AU - Bostroem, Ann Charlotte
AU - Carusi, Annamaria
AU - Coecke, Sandra
AU - Concha, Rachel
AU - Daskalopoulos, Evangelos P.
AU - Debernardi, Francesca
AU - Edrosa, Eizleayne
AU - Edwards, Steve W.
AU - Filipovska, Julija
AU - Garcia-Reyero, Natàlia
AU - Gavins, Felicity N.E.
AU - Halappanavar, Sabina
AU - Hargreaves, Alan J.
AU - Hogberg, Helena T.
AU - Huynh, Mylène T.
AU - Jacobson, Daniel
AU - Josephs- Spaulding, Jonathan
AU - Kim, Young Jun
AU - Kong, Hyun Joon
AU - Krebs, Catharine E.
AU - Lam, Ann
AU - Landesmann, Brigitte
AU - Layton, Adrienne Racanelli
AU - Lee, Yong Oh
AU - Macmillan, Donna S.
AU - Mantovani, Alberto
AU - Margiotta-Casaluci, Luigi
AU - Martens, Marvin
AU - Masereeuw, Rosalinde
AU - Mayasich, Sally A.
AU - Mei, Liang Merlin
AU - Mortensen, Holly
AU - Munoz, Amalia
AU - Nymark, Penny
AU - Ohayon, Elan
AU - Ojasi, Joshi Manoj
AU - Paini, Alicia
AU - Parissis, Nikolaos
AU - Parvatam, Surat
AU - Pistollato, Francesca
AU - Sachana, Magdalini
AU - Sørli, Jorid Birkelund
AU - Sullivan, Kristie M.
AU - Sund, Jukka
AU - Tanabe, Shihori
AU - Tsaioun, Katya
AU - Vinken, Mathieu
AU - Viviani, Laura
AU - Waspe, Jennifer
AU - Willett, Catherine
AU - Wittwehr, Clemens
N1 - Publisher Copyright:
© 2022 ALTEX Edition. All rights reserved.
PY - 2022
Y1 - 2022
N2 - On April 28-29, 2021, 50 scientists from different fields of expertise met for the 3rd online CIAO workshop. The CIAO project "Modelling the Pathogenesis of COVID-19 using the Adverse Outcome Pathway (AOP) framework" aims at building a holistic assembly of the available scientific knowledge on COVID-19 using the AOP framework. An individual AOP depicts the disease progression from the initial contact with the SARS-CoV-2 virus through biological key events (KE) toward an adverse outcome such as respiratory distress, anosmia or multiorgan failure. Assembling the individual AOPs into a network highlights shared KEs as central biological nodes involved in multiple outcomes observed in COVID-19 patients. During the workshop, the KEs and AOPs established so far by the CIAO members were presented and positioned on a timeline of the disease course. Modulating factors influencing the progression and severity of the disease were also addressed as well as factors beyond purely biological phenomena. CIAO relies on an interdisciplinary crowdsourcing effort, therefore, approaches to expand the CIAO network by widening the crowd and reaching stakeholders were also discussed. To conclude the workshop, it was decided that the AOPs/KEs will be further consolidated, integrating virus variants and long COVID when relevant, while an outreach campaign will be launched to broaden the CIAO scientific crowd.
AB - On April 28-29, 2021, 50 scientists from different fields of expertise met for the 3rd online CIAO workshop. The CIAO project "Modelling the Pathogenesis of COVID-19 using the Adverse Outcome Pathway (AOP) framework" aims at building a holistic assembly of the available scientific knowledge on COVID-19 using the AOP framework. An individual AOP depicts the disease progression from the initial contact with the SARS-CoV-2 virus through biological key events (KE) toward an adverse outcome such as respiratory distress, anosmia or multiorgan failure. Assembling the individual AOPs into a network highlights shared KEs as central biological nodes involved in multiple outcomes observed in COVID-19 patients. During the workshop, the KEs and AOPs established so far by the CIAO members were presented and positioned on a timeline of the disease course. Modulating factors influencing the progression and severity of the disease were also addressed as well as factors beyond purely biological phenomena. CIAO relies on an interdisciplinary crowdsourcing effort, therefore, approaches to expand the CIAO network by widening the crowd and reaching stakeholders were also discussed. To conclude the workshop, it was decided that the AOPs/KEs will be further consolidated, integrating virus variants and long COVID when relevant, while an outreach campaign will be launched to broaden the CIAO scientific crowd.
UR - http://www.scopus.com/inward/record.url?scp=85128487716&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85128487716&partnerID=8YFLogxK
U2 - 10.14573/altex.2112161
DO - 10.14573/altex.2112161
M3 - Article
C2 - 35032963
AN - SCOPUS:85128487716
SN - 1868-596X
VL - 39
SP - 322
EP - 335
JO - ALTEX
JF - ALTEX
IS - 2
ER -