TY - JOUR
T1 - COVID-19 in hospitalized lung and non-lung solid organ transplant recipients
T2 - A comparative analysis from a multicenter study
AU - the UW COVID-19 SOT Study Team
AU - Heldman, Madeleine R.
AU - Kates, Olivia S.
AU - Safa, Kassem
AU - Kotton, Camille N.
AU - Georgia, Sarah J.
AU - Steinbrink, Julie M.
AU - Alexander, Barbara D.
AU - Hemmersbach-Miller, Marion
AU - Blumberg, Emily A.
AU - Crespo, Maria M.
AU - Multani, Ashrit
AU - Lewis, Angelica V.
AU - Eugene Beaird, Omer
AU - Haydel, Brandy
AU - La Hoz, Ricardo M.
AU - Moni, Lisset
AU - Condor, Yesabeli
AU - Flores, Sandra
AU - Munoz, Carlos G.
AU - Guitierrez, Juan
AU - Diaz, Esther I.
AU - Diaz, Daniela
AU - Vianna, Rodrigo
AU - Guerra, Giselle
AU - Loebe, Matthias
AU - Rakita, Robert M.
AU - Malinis, Maricar
AU - Azar, Marwan M.
AU - Hemmige, Vagish
AU - McCort, Margaret E.
AU - Chaudhry, Zohra S.
AU - Singh, Pooja
AU - Hughes, Kailey
AU - Velioglu, Arzu
AU - Yabu, Julie M.
AU - Morillis, Jose A.
AU - Mehta, Sapna A.
AU - Tanna, Sajal D.
AU - Ison, Michael G.
AU - Tomic, Rade
AU - Candace Derenge, Ariella
AU - van Duin, David
AU - Maximin, Adrienne
AU - Gilbert, Carlene
AU - Goldman, Jason D.
AU - Sehgal, Sameep
AU - Weisshaar, Dana
AU - Girgis, Reda E.
AU - Nelson, Joanna
AU - Lease, Erika D.
N1 - Publisher Copyright:
© 2021 The American Society of Transplantation and the American Society of Transplant Surgeons
PY - 2021/8
Y1 - 2021/8
N2 - Lung transplant recipients (LTR) with coronavirus disease 2019 (COVID-19) may have higher mortality than non-lung solid organ transplant recipients (SOTR), but direct comparisons are limited. Risk factors for mortality specifically in LTR have not been explored. We performed a multicenter cohort study of adult SOTR with COVID-19 to compare mortality by 28 days between hospitalized LTR and non-lung SOTR. Multivariable logistic regression models were used to assess comorbidity-adjusted mortality among LTR vs. non-lung SOTR and to determine risk factors for death in LTR. Of 1,616 SOTR with COVID-19, 1,081 (66%) were hospitalized including 120/159 (75%) LTR and 961/1457 (66%) non-lung SOTR (p =.02). Mortality was higher among LTR compared to non-lung SOTR (24% vs. 16%, respectively, p =.032), and lung transplant was independently associated with death after adjusting for age and comorbidities (aOR 1.7, 95% CI 1.0–2.6, p =.04). Among LTR, chronic lung allograft dysfunction (aOR 3.3, 95% CI 1.0–11.3, p =.05) was the only independent risk factor for mortality and age >65 years, heart failure and obesity were not independently associated with death. Among SOTR hospitalized for COVID-19, LTR had higher mortality than non-lung SOTR. In LTR, chronic allograft dysfunction was independently associated with mortality.
AB - Lung transplant recipients (LTR) with coronavirus disease 2019 (COVID-19) may have higher mortality than non-lung solid organ transplant recipients (SOTR), but direct comparisons are limited. Risk factors for mortality specifically in LTR have not been explored. We performed a multicenter cohort study of adult SOTR with COVID-19 to compare mortality by 28 days between hospitalized LTR and non-lung SOTR. Multivariable logistic regression models were used to assess comorbidity-adjusted mortality among LTR vs. non-lung SOTR and to determine risk factors for death in LTR. Of 1,616 SOTR with COVID-19, 1,081 (66%) were hospitalized including 120/159 (75%) LTR and 961/1457 (66%) non-lung SOTR (p =.02). Mortality was higher among LTR compared to non-lung SOTR (24% vs. 16%, respectively, p =.032), and lung transplant was independently associated with death after adjusting for age and comorbidities (aOR 1.7, 95% CI 1.0–2.6, p =.04). Among LTR, chronic lung allograft dysfunction (aOR 3.3, 95% CI 1.0–11.3, p =.05) was the only independent risk factor for mortality and age >65 years, heart failure and obesity were not independently associated with death. Among SOTR hospitalized for COVID-19, LTR had higher mortality than non-lung SOTR. In LTR, chronic allograft dysfunction was independently associated with mortality.
KW - clinical research/practice
KW - infection and infectious agents - viral
KW - infectious disease
KW - lung (allograft) function/dysfunction
KW - lung disease: infectious
KW - lung transplantation/pulmonology
KW - organ transplantation in general
UR - http://www.scopus.com/inward/record.url?scp=85110355028&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85110355028&partnerID=8YFLogxK
U2 - 10.1111/ajt.16692
DO - 10.1111/ajt.16692
M3 - Article
C2 - 34008917
AN - SCOPUS:85110355028
SN - 1600-6135
VL - 21
SP - 2774
EP - 2784
JO - American Journal of Transplantation
JF - American Journal of Transplantation
IS - 8
ER -