TY - JOUR
T1 - COVID-19 in a patient with a flare of systemic lupus erythematosus
T2 - A rare case-report
AU - Alharthy, Abdulrahman
AU - Faqihi, Fahad
AU - Nasim, Nasir
AU - Noor, Alfateh
AU - Akhtar, Saima
AU - Balshi, Ahmed
AU - Balhamar, Abdullah
AU - Alqahtani, Saleh A.
AU - Memish, Ziad A.
AU - Karakitsos, Dimitrios
N1 - Publisher Copyright:
© 2020 The Author(s)
PY - 2020/1
Y1 - 2020/1
N2 - This is a rare case-report of a young female with systemic lupus erythematosus and end-stage kidney disease (on maintenance hemodialysis) who was admitted to our intensive care unit due to life-threatening COVID-19. The patient was diagnosed with a flare of lupus; while being on maintenance hydroxychloroquine therapy. However, after the administration of steroids she made an uneventful recovery and was discharged home. In this report, the diagnostic dilemmas and the therapeutic challenges due to the overlapping clinical, imaging, and laboratory findings between lupus and COVID-19 pneumonitis are outlined. In conclusion, patients with lupus may be affected by COVID-19 despite the administration of hydroxychloroquine. The administration of steroids may have a beneficial effect on mitigating both the flare of SLE and the COVID-19 associated hyperinflammation.
AB - This is a rare case-report of a young female with systemic lupus erythematosus and end-stage kidney disease (on maintenance hemodialysis) who was admitted to our intensive care unit due to life-threatening COVID-19. The patient was diagnosed with a flare of lupus; while being on maintenance hydroxychloroquine therapy. However, after the administration of steroids she made an uneventful recovery and was discharged home. In this report, the diagnostic dilemmas and the therapeutic challenges due to the overlapping clinical, imaging, and laboratory findings between lupus and COVID-19 pneumonitis are outlined. In conclusion, patients with lupus may be affected by COVID-19 despite the administration of hydroxychloroquine. The administration of steroids may have a beneficial effect on mitigating both the flare of SLE and the COVID-19 associated hyperinflammation.
KW - Acute respiratory failure
KW - COVID-19
KW - End-stage kidney disease
KW - Hydroxychloroquine
KW - Steroid therapy
KW - Systemic lupus erythematosus
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U2 - 10.1016/j.rmcr.2020.101252
DO - 10.1016/j.rmcr.2020.101252
M3 - Article
C2 - 33078093
AN - SCOPUS:85093654290
SN - 2213-0071
VL - 31
JO - Respiratory Medicine CME
JF - Respiratory Medicine CME
M1 - 101252
ER -