COVID-19 in a patient with a flare of systemic lupus erythematosus: A rare case-report

Abdulrahman Alharthy; Fahad Faqihi; Nasir Nasim; Alfateh Noor; Saima Akhtar; Ahmed Balshi; Abdullah Balhamar; Saleh A. Alqahtani; Ziad A. Memish; Dimitrios Karakitsos

doi:10.1016/j.rmcr.2020.101252

COVID-19 in a patient with a flare of systemic lupus erythematosus: A rare case-report

Abdulrahman Alharthy, Fahad Faqihi, Nasir Nasim, Alfateh Noor, Saima Akhtar, Ahmed Balshi, Abdullah Balhamar, Saleh A. Alqahtani, Ziad A. Memish, Dimitrios Karakitsos

School of Medicine

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

This is a rare case-report of a young female with systemic lupus erythematosus and end-stage kidney disease (on maintenance hemodialysis) who was admitted to our intensive care unit due to life-threatening COVID-19. The patient was diagnosed with a flare of lupus; while being on maintenance hydroxychloroquine therapy. However, after the administration of steroids she made an uneventful recovery and was discharged home. In this report, the diagnostic dilemmas and the therapeutic challenges due to the overlapping clinical, imaging, and laboratory findings between lupus and COVID-19 pneumonitis are outlined. In conclusion, patients with lupus may be affected by COVID-19 despite the administration of hydroxychloroquine. The administration of steroids may have a beneficial effect on mitigating both the flare of SLE and the COVID-19 associated hyperinflammation.

Original language	English (US)
Article number	101252
Journal	Respiratory Medicine Case Reports
Volume	31
DOIs	https://doi.org/10.1016/j.rmcr.2020.101252
State	Published - Jan 2020

Keywords

Acute respiratory failure
COVID-19
End-stage kidney disease
Hydroxychloroquine
Steroid therapy
Systemic lupus erythematosus

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

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title = "COVID-19 in a patient with a flare of systemic lupus erythematosus: A rare case-report",

abstract = "This is a rare case-report of a young female with systemic lupus erythematosus and end-stage kidney disease (on maintenance hemodialysis) who was admitted to our intensive care unit due to life-threatening COVID-19. The patient was diagnosed with a flare of lupus; while being on maintenance hydroxychloroquine therapy. However, after the administration of steroids she made an uneventful recovery and was discharged home. In this report, the diagnostic dilemmas and the therapeutic challenges due to the overlapping clinical, imaging, and laboratory findings between lupus and COVID-19 pneumonitis are outlined. In conclusion, patients with lupus may be affected by COVID-19 despite the administration of hydroxychloroquine. The administration of steroids may have a beneficial effect on mitigating both the flare of SLE and the COVID-19 associated hyperinflammation.",

keywords = "Acute respiratory failure, COVID-19, End-stage kidney disease, Hydroxychloroquine, Steroid therapy, Systemic lupus erythematosus",

author = "Abdulrahman Alharthy and Fahad Faqihi and Nasir Nasim and Alfateh Noor and Saima Akhtar and Ahmed Balshi and Abdullah Balhamar and Alqahtani, {Saleh A.} and Memish, {Ziad A.} and Dimitrios Karakitsos",

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year = "2020",

month = jan,

doi = "10.1016/j.rmcr.2020.101252",

language = "English (US)",

volume = "31",

journal = "Respiratory Medicine CME",

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T1 - COVID-19 in a patient with a flare of systemic lupus erythematosus

T2 - A rare case-report

AU - Alharthy, Abdulrahman

AU - Faqihi, Fahad

AU - Nasim, Nasir

AU - Noor, Alfateh

AU - Akhtar, Saima

AU - Balshi, Ahmed

AU - Balhamar, Abdullah

AU - Alqahtani, Saleh A.

AU - Memish, Ziad A.

AU - Karakitsos, Dimitrios

PY - 2020/1

Y1 - 2020/1

N2 - This is a rare case-report of a young female with systemic lupus erythematosus and end-stage kidney disease (on maintenance hemodialysis) who was admitted to our intensive care unit due to life-threatening COVID-19. The patient was diagnosed with a flare of lupus; while being on maintenance hydroxychloroquine therapy. However, after the administration of steroids she made an uneventful recovery and was discharged home. In this report, the diagnostic dilemmas and the therapeutic challenges due to the overlapping clinical, imaging, and laboratory findings between lupus and COVID-19 pneumonitis are outlined. In conclusion, patients with lupus may be affected by COVID-19 despite the administration of hydroxychloroquine. The administration of steroids may have a beneficial effect on mitigating both the flare of SLE and the COVID-19 associated hyperinflammation.

AB - This is a rare case-report of a young female with systemic lupus erythematosus and end-stage kidney disease (on maintenance hemodialysis) who was admitted to our intensive care unit due to life-threatening COVID-19. The patient was diagnosed with a flare of lupus; while being on maintenance hydroxychloroquine therapy. However, after the administration of steroids she made an uneventful recovery and was discharged home. In this report, the diagnostic dilemmas and the therapeutic challenges due to the overlapping clinical, imaging, and laboratory findings between lupus and COVID-19 pneumonitis are outlined. In conclusion, patients with lupus may be affected by COVID-19 despite the administration of hydroxychloroquine. The administration of steroids may have a beneficial effect on mitigating both the flare of SLE and the COVID-19 associated hyperinflammation.

KW - Acute respiratory failure

KW - COVID-19

KW - End-stage kidney disease

KW - Hydroxychloroquine

KW - Steroid therapy

KW - Systemic lupus erythematosus

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ER -

COVID-19 in a patient with a flare of systemic lupus erythematosus: A rare case-report

Abstract

Keywords

ASJC Scopus subject areas

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