@article{48ee112957cf4181b09e41ff79d2c270,
title = "COVID-19 coagulopathy and thrombosis: Analysis of hospital protocols in response to the rapidly evolving pandemic",
abstract = "As the Coronavirus disease 2019 (COVID-19) pandemic spread to the US, so too did descriptions of an associated coagulopathy and thrombotic complications. Hospitals created institutional protocols for inpatient management of COVID-19 coagulopathy and thrombosis in response to this developing data. We collected and analyzed protocols from 21 US academic medical centers developed between January and May 2020. We found greatest consensus on recommendations for heparin-based pharmacologic venous thromboembolism (VTE) prophylaxis in COVID-19 patients without contraindications. Protocols differed regarding incorporation of D-dimer tests, dosing of VTE prophylaxis, indications for post-discharge pharmacologic VTE prophylaxis, how to evaluate for VTE, and the use of empiric therapeutic anticoagulation. These findings support ongoing efforts to establish international, evidence-based guidelines.",
keywords = "Anticoagulation, Coagulopathy, Coronavirus, Deep vein thrombosis (DVT), Pulmonary embolism (PE), Thrombosis, Venous thromboembolism (VTE)",
author = "{the Hospital Medicine Reengineering Network (HOMERuN)} and Parks, {Anna L.} and Auerbach, {Andrew D.} and Schnipper, {Jeffrey L.} and Anstey, {James E.} and Sterken, {David G.} and Hecht, {Todd E.H.} and Fang, {Margaret C.} and Vaughn, {Valerie M.} and Dunn, {Andrew S.} and Linker, {Anne S.} and Hunt, {Daniel P.} and Choi, {Justin J.} and Brotman, {Daniel J.} and Streiff, {Michael B.} and Mattison, {Melissa L.P.} and Pappas, {Matthew A.} and Greysen, {S. Ryan} and Hemsey, {David F.} and Kwame Dapaah-Afriyie and Neera Ahuja and Collins, {William J.} and Herzig, {Shoshana J.} and Sanjay Bhandari and Schumacher, {Eric R.} and Duggirala, {Vijay S.} and O'Leary, {Kevin J.} and Menard, {Geraldine E.} and Lin, {Michael Y.}",
note = "Funding Information: Dr. Fang reports that research reported in this publication was supported by the National Heart, Lung, And Blood Institute of the National Institutes of Health under Award Number K24HL141354. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Funding Information: Dr. Auerbach reports that research reported in this publication was supported by the Gordon and Betty Moore Foundation. The content is solely the responsibility of the authors and does not necessarily represent the official views of the Gordon and Betty Moore Foundation. Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",
year = "2020",
month = dec,
doi = "10.1016/j.thromres.2020.09.018",
language = "English (US)",
volume = "196",
pages = "355--358",
journal = "Thrombosis research",
issn = "0049-3848",
publisher = "Elsevier Limited",
}