Covariance mapping in matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

Andrew B. Feldman, Miquel Antoine, Jeffrey S. Lin, Plamen A. Demirev

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


A novel method for acquisition and numerical analysis of matrix-assisted laser desorption/ionization (MALDI) time-offlight mass spectral data is described. The digitized ion current transient from each consecutive laser shot is first acquired and stored independently. Subsequently, statistical correlation parameters between all stored transients are computed. We illustrate the uses of this event-by-event analysis method for studies of sample surface heterogeneity as well as for elucidating the mechanisms of ion formation in MALDI. Other potential applications of the method are also outlined.

Original languageEnglish (US)
Pages (from-to)991-995
Number of pages5
JournalRapid Communications in Mass Spectrometry
Issue number9
StatePublished - 2003
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy
  • Organic Chemistry


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