Courting a cure for Fragile X

Gül Dölen; Mark F. Bear

doi:10.1016/j.neuron.2005.02.021

Courting a cure for Fragile X

Gül Dölen, Mark F. Bear

School of Medicine

Research output: Contribution to journal › Short survey › peer-review

28 Scopus citations

Abstract

Fragile X syndrome is the most common heritable cause of mental retardation. Previous work has suggested that overactive signaling by group I metabotropic glutamate receptors (mGluRs) may be a mechanism underlying many of the disease symptoms. As a test of this theory, McBride et al. show that in a Drosophila model for Fragile X syndrome, treatment with mGluR antagonists can rescue short-term memory, courtship, and mushroom body defects.

Original language	English (US)
Pages (from-to)	642-644
Number of pages	3
Journal	Neuron
Volume	45
Issue number	5
DOIs	https://doi.org/10.1016/j.neuron.2005.02.021
State	Published - Mar 3 2005

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/j.neuron.2005.02.021

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Courting a cure for Fragile X

Abstract

ASJC Scopus subject areas

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