Costimulation of T cells for tumor immunity

Lieping Chen, Peter S. Linsley, Karl Erik Hellström

Research output: Contribution to journalArticlepeer-review


Tumor specific antigens can be demonstrated on many neoplasms by immunization and challenge experiments; however, these antigens do not normally elicit a sufficiently strong immune response to prevent tumor growth in immunocompetent hosts. Recent studies have demonstrated that efficient activation of T cells requires costimulation of the CD28 receptor via the B7 molecule on antigen-presenting cells. Inadequate costimulation of tumor-reactive T cells may contribute to the fact that antigenic tumors are not normally rejected by the immune system, and weak anti-tumor immune responses may be amplified by upregulation of CD28 triggering.

Original languageEnglish (US)
Pages (from-to)483-486
Number of pages4
JournalTrends in Immunology
Issue number10
StatePublished - Oct 1993
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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