Costimulation by CD48 and B7-1 induces immunity against poorly immunogenic tumors

Yiwen Li, Karl Erik Hellström, Stephanie Ashe Newby, Lieping Chen

Research output: Contribution to journalArticlepeer-review

84 Scopus citations


Genetic modification of many types of mouse tumors to express the B7-1 or B7-2 molecules, natural ligands for the T cell-costimulatory molecule CD28, increases their immunogenicity. However, even after transfection with the B7-1 and/or B7-2 genes, poorly immunogenic tumors fail to elicit an efficient immune response. We report here that two such tumors, the Ag104A sarcoma and the K1735-M2 melanoma, become immunogenic after transfection of the genes encoding murine B7-1 together with CD48, which is the natural ligand for CD2. Tumor-specific CD8+ cytotoxic T lymphocytes were readily generated and were effective for adoptive immunotherapy of metastasis induced by wild-type Ag104A sarcoma cells. A similar approach may be useful for developing therapy for other poorly immunogenic tumors, including those in humans.

Original languageEnglish (US)
Pages (from-to)639-644
Number of pages6
JournalJournal of Experimental Medicine
Issue number2
StatePublished - Feb 1 1996
Externally publishedYes

ASJC Scopus subject areas

  • Immunology


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