Cost-utility of routine endometrial evaluation before le fort colpocleisis

Padma Kandadai, Michael Flynn, Susan Zweizig, Danielle Patterson

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Introduction: Routine preoperative evaluation of the endometrium before Le Fort colpocleisis is often recommended. There are no data, however, to support this practice. In select patients, it may not be a necessary addition to the preoperative evaluation of Le Fort colpocleisis. Methods: A decision analysis model was created to compare uterine evaluation, by either endometrial (EM) biopsy or transvaginal ultrasound, to no evaluation for a hypothetical cohort of women undergoing Le Fort colpocleisis. We assumed the absence of risk factors for EM cancer. Probabilities and health outcome utilities were obtained from literature review. Medicare charges were used to estimate cost in 2012 US dollars. Cost-utility analysis was performed using US recommendations from a health plan perspective. Results: At willingness-to-pay thresholds of $50, 000 and $100, 000, no evaluation is superior to both biopsy and ultrasound. At a 64% probability of cancer, biopsy is more cost-effective than no evaluation and ultrasound. Conclusions: Compared to biopsy and ultrasound, in low-risk women, no EM evaluation before Le Fort colpocleisis demonstrates superior cost-utility.

Original languageEnglish (US)
Pages (from-to)168-173
Number of pages6
JournalFemale Pelvic Medicine and Reconstructive Surgery
Issue number3
StatePublished - 2014
Externally publishedYes


  • Cost-utility
  • Decision analysis
  • Endometrial biopsy
  • Le Fort colpocleisis
  • Transvaginal ultrasound

ASJC Scopus subject areas

  • Surgery
  • Obstetrics and Gynecology
  • Urology


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