Cost-effectiveness of directly observed versus self-administered therapy for tuberculosis

Richard D. Moore, C. Patrick Chaulk, Robert Griffiths, Solange Cavalcante, Richard E. Chaisson

Research output: Contribution to journalArticlepeer-review

81 Scopus citations


Decision analysis was used to compare three alternative strategies for a 6-mo course of treatment for tuberculosis: directly observed drug therapy (DOT), self-administered fixed-dose combination drug therapy, and self- administered conventional individual drug therapy. Estimates of effectiveness were obtained from the published literature. Estimates of costs were obtained from the literature and the Baltimore City Health Department. Both DOT and fixed-dose combination therapy were less costly and more effective than conventional therapy, although DOT was most cost-effective. In total, the average cost per patient treated was $13,925 for DOT, $13,959 for fixed-dose combination therapy, and $15,003 for conventional therapy. Per 1,000 patients treated, 31 relapses and three deaths could be expected for DOT, 96 relapses and eight deaths for fixed-dose combination therapy, and 133 relapses and 13 deaths for conventional therapy. The marginal cost-effectiveness of DOT relative to fixed-dose combination therapy was most sensitive to variability in the direct cost of DOT and less sensitive to relapse rates for DOT and fixed-dose combination therapy. The inferior cost-effectiveness of conventional therapy was not sensitive to plausible variability in cost or effectiveness. Both DOT and fixed-dose combination therapy were cost- effective relative to conventional therapy, although DOT is probably most cost-effective.

Original languageEnglish (US)
Pages (from-to)1013-1019
Number of pages7
JournalAmerican journal of respiratory and critical care medicine
Issue number4 I
StatePublished - 1996

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine


Dive into the research topics of 'Cost-effectiveness of directly observed versus self-administered therapy for tuberculosis'. Together they form a unique fingerprint.

Cite this