Cortisol induction by poly ICLC: Implications for clinical trials of interferon

C. T. Bever; H. F. McFarland; H. B. Levy; D. E. McFarlin

Cortisol induction by poly ICLC: Implications for clinical trials of interferon

C. T. Bever, H. F. McFarland, H. B. Levy, D. E. McFarlin

Research output: Contribution to journal › Article › peer-review

Abstract

Because interferon injections have recently been reported to induce cortisol in cancer patients, we retrospectively reviewed cortisol levels obtained during a preliminary trial of the interferon inducer polyriboinosinic polyribocytidylic acid in poly-L-lysine and carboxymethylcellulose (poly ICLC) in multiple sclerosis patients to determine if significant cortisol induction occurred. Analysis of data from 51 poly ICLC infusions in 6 men and 4 women showed elevated cortisol levels 4 to 16 hours after infusion, with hematological changes consistent with steroid effects. The highest cortisol levels observed were in 2 patients who improved during the treatment period, but there was no clear relationship between cortisol levels and clinical outcome in the group as a whole.

Original language	English (US)
Pages (from-to)	196-199
Number of pages	4
Journal	Annals of Neurology
Volume	23
Issue number	2
State	Published - 1988
Externally published	Yes

ASJC Scopus subject areas

General Neuroscience

Cite this

@article{0604e7a19a744ca8ba79342833c0aa11,

title = "Cortisol induction by poly ICLC: Implications for clinical trials of interferon",

abstract = "Because interferon injections have recently been reported to induce cortisol in cancer patients, we retrospectively reviewed cortisol levels obtained during a preliminary trial of the interferon inducer polyriboinosinic polyribocytidylic acid in poly-L-lysine and carboxymethylcellulose (poly ICLC) in multiple sclerosis patients to determine if significant cortisol induction occurred. Analysis of data from 51 poly ICLC infusions in 6 men and 4 women showed elevated cortisol levels 4 to 16 hours after infusion, with hematological changes consistent with steroid effects. The highest cortisol levels observed were in 2 patients who improved during the treatment period, but there was no clear relationship between cortisol levels and clinical outcome in the group as a whole.",

author = "Bever, {C. T.} and McFarland, {H. F.} and Levy, {H. B.} and McFarlin, {D. E.}",

year = "1988",

language = "English (US)",

volume = "23",

pages = "196--199",

journal = "Annals of Neurology",

issn = "0364-5134",

publisher = "John Wiley and Sons Inc.",

number = "2",

}

TY - JOUR

T1 - Cortisol induction by poly ICLC

T2 - Implications for clinical trials of interferon

AU - Bever, C. T.

AU - McFarland, H. F.

AU - Levy, H. B.

AU - McFarlin, D. E.

PY - 1988

Y1 - 1988

N2 - Because interferon injections have recently been reported to induce cortisol in cancer patients, we retrospectively reviewed cortisol levels obtained during a preliminary trial of the interferon inducer polyriboinosinic polyribocytidylic acid in poly-L-lysine and carboxymethylcellulose (poly ICLC) in multiple sclerosis patients to determine if significant cortisol induction occurred. Analysis of data from 51 poly ICLC infusions in 6 men and 4 women showed elevated cortisol levels 4 to 16 hours after infusion, with hematological changes consistent with steroid effects. The highest cortisol levels observed were in 2 patients who improved during the treatment period, but there was no clear relationship between cortisol levels and clinical outcome in the group as a whole.

AB - Because interferon injections have recently been reported to induce cortisol in cancer patients, we retrospectively reviewed cortisol levels obtained during a preliminary trial of the interferon inducer polyriboinosinic polyribocytidylic acid in poly-L-lysine and carboxymethylcellulose (poly ICLC) in multiple sclerosis patients to determine if significant cortisol induction occurred. Analysis of data from 51 poly ICLC infusions in 6 men and 4 women showed elevated cortisol levels 4 to 16 hours after infusion, with hematological changes consistent with steroid effects. The highest cortisol levels observed were in 2 patients who improved during the treatment period, but there was no clear relationship between cortisol levels and clinical outcome in the group as a whole.

UR - http://www.scopus.com/inward/record.url?scp=0023874664&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023874664&partnerID=8YFLogxK

M3 - Article

C2 - 2454067

AN - SCOPUS:0023874664

SN - 0364-5134

VL - 23

SP - 196

EP - 199

JO - Annals of Neurology

JF - Annals of Neurology

IS - 2

ER -

Cortisol induction by poly ICLC: Implications for clinical trials of interferon

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this