Cortisol induction by poly ICLC: Implications for clinical trials of interferon

C. T. Bever, H. F. McFarland, H. B. Levy, D. E. McFarlin

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Because interferon injections have recently been reported to induce cortisol in cancer patients, we retrospectively reviewed cortisol levels obtained during a preliminary trial of the interferon inducer polyriboinosinic polyribocytidylic acid in poly-L-lysine and carboxymethylcellulose (poly ICLC) in multiple sclerosis patients to determine if significant cortisol induction occurred. Analysis of data from 51 poly ICLC infusions in 6 men and 4 women showed elevated cortisol levels 4 to 16 hours after infusion, with hematological changes consistent with steroid effects. The highest cortisol levels observed were in 2 patients who improved during the treatment period, but there was no clear relationship between cortisol levels and clinical outcome in the group as a whole.

Original languageEnglish (US)
Pages (from-to)196-199
Number of pages4
JournalAnnals of Neurology
Issue number2
StatePublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)


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