Cortisol induction by poly ICLC: Implications for clinical trials of interferon

C. T. Bever; H. F. McFarland; H. B. Levy; D. E. McFarlin

Cortisol induction by poly ICLC: Implications for clinical trials of interferon

C. T. Bever, H. F. McFarland, H. B. Levy, D. E. McFarlin

Research output: Contribution to journal › Article › peer-review

Abstract

Because interferon injections have recently been reported to induce cortisol in cancer patients, we retrospectively reviewed cortisol levels obtained during a preliminary trial of the interferon inducer polyriboinosinic polyribocytidylic acid in poly-L-lysine and carboxymethylcellulose (poly ICLC) in multiple sclerosis patients to determine if significant cortisol induction occurred. Analysis of data from 51 poly ICLC infusions in 6 men and 4 women showed elevated cortisol levels 4 to 16 hours after infusion, with hematological changes consistent with steroid effects. The highest cortisol levels observed were in 2 patients who improved during the treatment period, but there was no clear relationship between cortisol levels and clinical outcome in the group as a whole.

Original language	English (US)
Pages (from-to)	196-199
Number of pages	4
Journal	Annals of Neurology
Volume	23
Issue number	2
State	Published - 1988
Externally published	Yes

ASJC Scopus subject areas

Neuroscience(all)

Cite this

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title = "Cortisol induction by poly ICLC: Implications for clinical trials of interferon",

abstract = "Because interferon injections have recently been reported to induce cortisol in cancer patients, we retrospectively reviewed cortisol levels obtained during a preliminary trial of the interferon inducer polyriboinosinic polyribocytidylic acid in poly-L-lysine and carboxymethylcellulose (poly ICLC) in multiple sclerosis patients to determine if significant cortisol induction occurred. Analysis of data from 51 poly ICLC infusions in 6 men and 4 women showed elevated cortisol levels 4 to 16 hours after infusion, with hematological changes consistent with steroid effects. The highest cortisol levels observed were in 2 patients who improved during the treatment period, but there was no clear relationship between cortisol levels and clinical outcome in the group as a whole.",

author = "Bever, {C. T.} and McFarland, {H. F.} and Levy, {H. B.} and McFarlin, {D. E.}",

year = "1988",

language = "English (US)",

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T2 - Implications for clinical trials of interferon

AU - Bever, C. T.

AU - McFarland, H. F.

AU - Levy, H. B.

AU - McFarlin, D. E.

PY - 1988

Y1 - 1988

N2 - Because interferon injections have recently been reported to induce cortisol in cancer patients, we retrospectively reviewed cortisol levels obtained during a preliminary trial of the interferon inducer polyriboinosinic polyribocytidylic acid in poly-L-lysine and carboxymethylcellulose (poly ICLC) in multiple sclerosis patients to determine if significant cortisol induction occurred. Analysis of data from 51 poly ICLC infusions in 6 men and 4 women showed elevated cortisol levels 4 to 16 hours after infusion, with hematological changes consistent with steroid effects. The highest cortisol levels observed were in 2 patients who improved during the treatment period, but there was no clear relationship between cortisol levels and clinical outcome in the group as a whole.

AB - Because interferon injections have recently been reported to induce cortisol in cancer patients, we retrospectively reviewed cortisol levels obtained during a preliminary trial of the interferon inducer polyriboinosinic polyribocytidylic acid in poly-L-lysine and carboxymethylcellulose (poly ICLC) in multiple sclerosis patients to determine if significant cortisol induction occurred. Analysis of data from 51 poly ICLC infusions in 6 men and 4 women showed elevated cortisol levels 4 to 16 hours after infusion, with hematological changes consistent with steroid effects. The highest cortisol levels observed were in 2 patients who improved during the treatment period, but there was no clear relationship between cortisol levels and clinical outcome in the group as a whole.

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JO - Annals of Neurology

JF - Annals of Neurology

IS - 2

ER -

Cortisol induction by poly ICLC: Implications for clinical trials of interferon

Abstract

ASJC Scopus subject areas

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