Corticotronpin-releasing hormone inhibits maternal behavior and induces pup-killing

Cort A. Pedersen; Jack D. Caldwell; Marsden McGuire; Dwight L. Evans

doi:10.1016/0024-3205(91)90278-J

Corticotronpin-releasing hormone inhibits maternal behavior and induces pup-killing

Cort A. Pedersen, Jack D. Caldwell, Marsden McGuire, Dwight L. Evans

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

Behavioral responses to stressors and the effects of stressors on maternal behavior change with mothering experience. Corticotropin-releasing hormone (CRH) is released by stressors and produces stress-like behavioral effects. We tested the effects of ICV infusion of ovine CRH (0.5-4 ug) on pup-directed behaviors in ovariectomized, ovarian steroid-treated virgin rats that were either naive to pups or that had three days of mothering experience. CRH inhibited maternal behavior in naive and experience rats in a dose-related manner. The magnitude and duration of inhibition, especially at the 1 ug dose, were less in rats with mothering experience. Higher doses of CRH (1 - 4 ug) significantly increased pup-killing in rats that were naive to pups. In contrast, CRH produced no pup-killing in rats with mothering experience.

Original language	English (US)
Pages (from-to)	1537-1546
Number of pages	10
Journal	Life Sciences
Volume	48
Issue number	16
DOIs	https://doi.org/10.1016/0024-3205(91)90278-J
State	Published - 1991
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/0024-3205(91)90278-J

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title = "Corticotronpin-releasing hormone inhibits maternal behavior and induces pup-killing",

abstract = "Behavioral responses to stressors and the effects of stressors on maternal behavior change with mothering experience. Corticotropin-releasing hormone (CRH) is released by stressors and produces stress-like behavioral effects. We tested the effects of ICV infusion of ovine CRH (0.5-4 ug) on pup-directed behaviors in ovariectomized, ovarian steroid-treated virgin rats that were either naive to pups or that had three days of mothering experience. CRH inhibited maternal behavior in naive and experience rats in a dose-related manner. The magnitude and duration of inhibition, especially at the 1 ug dose, were less in rats with mothering experience. Higher doses of CRH (1 - 4 ug) significantly increased pup-killing in rats that were naive to pups. In contrast, CRH produced no pup-killing in rats with mothering experience.",

author = "Pedersen, {Cort A.} and Caldwell, {Jack D.} and Marsden McGuire and Evans, {Dwight L.}",

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T1 - Corticotronpin-releasing hormone inhibits maternal behavior and induces pup-killing

AU - Pedersen, Cort A.

AU - Caldwell, Jack D.

AU - McGuire, Marsden

AU - Evans, Dwight L.

PY - 1991

Y1 - 1991

N2 - Behavioral responses to stressors and the effects of stressors on maternal behavior change with mothering experience. Corticotropin-releasing hormone (CRH) is released by stressors and produces stress-like behavioral effects. We tested the effects of ICV infusion of ovine CRH (0.5-4 ug) on pup-directed behaviors in ovariectomized, ovarian steroid-treated virgin rats that were either naive to pups or that had three days of mothering experience. CRH inhibited maternal behavior in naive and experience rats in a dose-related manner. The magnitude and duration of inhibition, especially at the 1 ug dose, were less in rats with mothering experience. Higher doses of CRH (1 - 4 ug) significantly increased pup-killing in rats that were naive to pups. In contrast, CRH produced no pup-killing in rats with mothering experience.

AB - Behavioral responses to stressors and the effects of stressors on maternal behavior change with mothering experience. Corticotropin-releasing hormone (CRH) is released by stressors and produces stress-like behavioral effects. We tested the effects of ICV infusion of ovine CRH (0.5-4 ug) on pup-directed behaviors in ovariectomized, ovarian steroid-treated virgin rats that were either naive to pups or that had three days of mothering experience. CRH inhibited maternal behavior in naive and experience rats in a dose-related manner. The magnitude and duration of inhibition, especially at the 1 ug dose, were less in rats with mothering experience. Higher doses of CRH (1 - 4 ug) significantly increased pup-killing in rats that were naive to pups. In contrast, CRH produced no pup-killing in rats with mothering experience.

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Corticotronpin-releasing hormone inhibits maternal behavior and induces pup-killing

Abstract

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