Cortical circumferential profile of SPECT cerebral perfusion in Alzheimer's disease

Gordon J. Harris; Jonathan M. Links; Godfrey D. Pearlson; Edwaldo E. Camargo

doi:10.1016/0925-4927(91)90008-E

Cortical circumferential profile of SPECT cerebral perfusion in Alzheimer's disease

Gordon J. Harris, Jonathan M. Links, Godfrey D. Pearlson, Edwaldo E. Camargo

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

We developed a semiautomatic method termed "cortical circumferential profiling" for objective analysis of cerebral cortex function in emission tomographic neuroimaging studies. This method treats cortex as a continuous ring near the outer brain edge. A computer algorithm samples the cortex at 60 contiguous, equiangular locations, using 1-cm² samples. These values are plotted as a function of cortical angle to produce the cortical circumferential profile. This method was used in a study of regional cerebral perfusion in 15 patients with Alzheimer's disease and 8 elderly control subjects using N-isopropyl [I-123]-iodoamphetamine. Cortical circumferential profiling decreases variability, examines the entire cortex within slices at preselected levels above the orbital-meatal line, and facilitates intrasubject and intersubject comparisons.

Original language	English (US)
Pages (from-to)	167-180
Number of pages	14
Journal	Psychiatry Research: Neuroimaging
Volume	40
Issue number	3
DOIs	https://doi.org/10.1016/0925-4927(91)90008-E
State	Published - Nov 1991

Keywords

Alzheimer's disease
Cerebral emission computed tomography
cortical circumferential profile
regional cerebral blood flow
semiautomated quantification

ASJC Scopus subject areas

Neuroscience (miscellaneous)
Radiology Nuclear Medicine and imaging
Psychiatry and Mental health

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10.1016/0925-4927(91)90008-E

Cite this

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AU - Links, Jonathan M.

AU - Pearlson, Godfrey D.

AU - Camargo, Edwaldo E.

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KW - Cerebral emission computed tomography

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Cortical circumferential profile of SPECT cerebral perfusion in Alzheimer's disease

Abstract

Keywords

ASJC Scopus subject areas

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