Cortical circumferential profile of SPECT cerebral perfusion in Alzheimer's disease

Gordon J. Harris, Jonathan M. Links, Godfrey D. Pearlson, Edwaldo E. Camargo

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


We developed a semiautomatic method termed "cortical circumferential profiling" for objective analysis of cerebral cortex function in emission tomographic neuroimaging studies. This method treats cortex as a continuous ring near the outer brain edge. A computer algorithm samples the cortex at 60 contiguous, equiangular locations, using 1-cm2 samples. These values are plotted as a function of cortical angle to produce the cortical circumferential profile. This method was used in a study of regional cerebral perfusion in 15 patients with Alzheimer's disease and 8 elderly control subjects using N-isopropyl [I-123]-iodoamphetamine. Cortical circumferential profiling decreases variability, examines the entire cortex within slices at preselected levels above the orbital-meatal line, and facilitates intrasubject and intersubject comparisons.

Original languageEnglish (US)
Pages (from-to)167-180
Number of pages14
JournalPsychiatry Research: Neuroimaging
Issue number3
StatePublished - Nov 1991


  • Alzheimer's disease
  • Cerebral emission computed tomography
  • cortical circumferential profile
  • regional cerebral blood flow
  • semiautomated quantification

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Psychiatry and Mental health


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